Expression of Circulating Microrna-199a and Microrna-155 in Chronic Viral Hepatitis B and Chronic Viral Hepatitis C

microRNA gene expression chronic viral hepatitis C chronic viral hepatitis B

Authors

  • Shavkat R. Aliyev Associate professor, Microbiology, virology and immunology, Tashkent Medical Academy, Tashkent, Uzbekistan
  • Ulug‘bek M. Аbdullayev Senior Lecturern, Department of Microbiology, virulogy and immunology, Tashkent Medical Academy, Tashkent, Uzbekistan
October 16, 2024

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Viral hepatitis is one of the significant problems of hepatology in the world. Chronic viral hepatitis is known to have a high tendency to transform into liver cirrhosis and hepatocellular carcinoma. The high heterogeneity of the genomes of viral hepatitis and especially hepatitis C makes molecular characterization based not only on the determination of gene mutations and gene expression profiles, but also on new biological markers, fundamentally important. These new biomarkers are microRNAs (microRNA, miRNA, miR). Currently, a large amount of knowledge has been accumulated about changes in the expression of microRNAs in various pathologies, including chronic hepatitis, which makes it possible to create diagnostic and prognostic criteria based on microRNAs.

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