Abstract:

The current problems of the prevention of infections related to the provision of medical care (ISMP) that arise at the present stage, in particular, the spread of antibiotic resistance, are discussed.It is noted that currently, in terms of reducing the risk of developing resistance of pathogenic microorganisms, it is necessary to take into account the phenomenon of antibiotic tolerance of bacteria, which is associated with a decrease in the level of metabolism, cessation of cell growth and shutdown of targets for antibiotics. Such persistent forms of microorganisms ensure the survival of the bacterial population, but not reproduction in the presence of lethal doses of antimicrobials. This kind of phenotypic resistance is not inherited, it is associated with such specific forms as growth in biofilms, and its carriers are a reservoir for the spread of resistance genes. Modern possibilities of avoiding the accumulation of persistent forms of ISMP pathogens, including the creation of antibiotic compositions and substances that block the adaptive reactions of the microorganism, are presented. Modern methods for the indication of ISMP pathogens existing in the hospital environment in the form of biofilms, as well as new methodological approaches to the destruction of such biofilms, are proposed.