Bacterial Infection in Patients with Dilated Cardiomyopathy

Dilatational cardiomyopathy (DCM) is a disease with polymorphic clinical manifestations. The most likely cause of DCM development is considered to be a viral infection, in particular associated with Coxsackie viruses (B1, B2), as well as with influenza viruses type A, herpes simplex, cytomegalovirus and, in some cases, with the human immunodeficiency virus. Patients with DCM are found to have various immunological disorders, the wide spectrum and heterogeneity of which indicate that various mechanisms may be involved in the pathogenesis of this disease. As is known, viral and bacterial infections can lead to damage to blood vessels and myocardium in humans and experimental animals, which is accompanied by a change in immunological reactivity macroorganism. In this case, disorders in the immune system may develop, causing the addition of a secondary infection. This is most clearly manifested in the syndrome of acquired immunodeficiency of the human being (AIDS), in which the development of a secondary infection caused by bacteria, fungi, protozoa and viruses is observed. Patients with immunological deficiency can become infected with low-virulence microorganisms, which are normally commensals. Immunological disorders in patients with DCM are characteristic of the syndrome of immunological deficiency (SID), which is caused by mucosuppressive factors, including viruses and parasites.

This work is devoted to the study of bacteremia and bacteriuria in patients with DCM.