Radiofrequency Ablation of Uterine Fibroids: A Review of Techniques, Efficacy and Outcomes

Authors

  • ISHIKA DEB NATH Student of International Faculty of Medicine, Tashkent Medical Academy, Uzbekistan
  • ABDURAZAKOVA MUKHAYYO DILSHODOVNA PhD of the Department of obstetrics and gynaecology, Tashkent Medical Academy, Uzbekistan

Keywords:

uterine fibroids, leiomyoma, radiofrequency ablation

Abstract

During the reproductive stage, uterine fibroids, which are benign smooth muscle tumors, can significantly impact a woman's quality of life. Pharmacologic treatment and surgical procedures like myomectomy and hysterectomy are included in traditional management. Radiofrequency ablation (RFA) has been a popular minimally invasive method for treating bothersome fibroids in recent years. This study covers RFA's indications, clinical efficacy, safety profiles, procedural methods, and potential future prospects in the treatment of fibroids. RFA is a good option for women looking for uterine-sparing therapy because of data from recent clinical trials and case series that demonstrate its effectiveness in symptom relief, uterine preservation, and accelerated recovery.

References

American Association of Gynecologic Laparoscopists [AAGL], 2023

Andersson KL, Wu E, Consoli C, Dubini V, Petraglia F, et al. (2024) Minimally Invasive Management of Uterine Fibroids - Role of Transvaginal Radiofrequency Ablation. J Reprod Med Gynecol Obstet 9: 163.

Arnreiter C, Oppelt P. A Systematic Review of the Treatment of Uterine Myomas Using Transcervical Ultrasound-Guided Radiofrequency Ablation with the Sonata System. J Minim Invasive Gynecol. 2021 Aug;28(8):1462-1469. doi: 10.1016/j.jmig.2021.04.009. Epub 2021 Apr 21. PMID: 33892184.

Babadjanova G. S. et al. Peculiarities of the Pregnancy in Women with Hepatobiliary System Pathology //Indian Journal of Forensic Medicine & Toxicology. – 2020. – Т. 14. – №. 4.

Bongers M, Quinn SD, Mueller MD, Krämer B, Tuschy B, Sütterlin M, Bassil Lasmar R, Chudnoff S, Thurkow A, De Wilde RL. Evaluation of uterine patency following transcervical uterine fibroid ablation with the Sonata system (the OPEN clinical trial). Eur J Obstet Gynecol Reprod Biol. 2019 Nov;242:122-125. doi: 10.1016/j.ejogrb.2019.09.013. Epub 2019 Sep 23. PMID: 31580964.

Bradley LD, Pasic RP, Miller LE. Clinical Performance of Radiofrequency Ablation for Treatment of Uterine Fibroids: Systematic Review and Meta-Analysis of Prospective Studies. J Laparoendosc Adv Surg Tech A. 2019 Dec;29(12):1507-1517. doi: 10.1089/lap.2019.0550. Epub 2019 Nov 8. PMID: 31702440; PMCID: PMC7387230.

Bradley LD, Pasic RP, Miller LE. Clinical Performance of Radiofrequency Ablation for Treatment of Uterine Fibroids: Systematic Review and Meta-Analysis of Prospective Studies. J Laparoendosc Adv Surg Tech A. 2019 Dec;29(12):1507-1517. doi: 10.1089/lap.2019.0550. Epub 2019 Nov 8. PMID: 31702440; PMCID: PMC7387230.

Christoffel L, Römer T, Schiermeier S. Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry (SAGE): Study Protocol and Preliminary Results. Med Devices (Auckl). 2021 Mar 3;14:77-84. doi: 10.2147/MDER.S301166. Erratum in: Med Devices (Auckl). 2021 Mar 15;14:85. doi: 10.2147/MDER.S309722. PMID: 33688276; PMCID: PMC7937398.

Das S., Mirzaeva D.B. Diagnostic and prognostic value of Platelet Indices as a potential biomarker in Preeclampsia: A Case-Control Study in a maternity hospital at Tashkent. – 2025.

Kwon CS, Abu-Alnadi ND. Updates on the Surgical Approach to Fibroids: The Importance of Radiofrequency Ablation. Semin Intervent Radiol. 2023 Aug 10;40(4):335-341. doi: 10.1055/s-0043-1770734. PMID: 37575346; PMCID: PMC10415057.

Laparoscopic Radiofrequency Ablation vs. Laparoscopic Myomectomy in the Treatment of Symptomatic Uterine Leiomyomas: A Meta-Analysis of Randomized Controlled Trials Published in 2021

Lin L, Ma H, Wang J, Guan H, Yang M, Tong X, Zou Y. Quality of Life, Adverse Events, and Reintervention Outcomes after Laparoscopic Radiofrequency Ablation for Symptomatic Uterine Fibroids: A Meta-Analysis. J Minim Invasive Gynecol. 2019 Mar-Apr;26(3):409-416. doi: 10.1016/j.jmig.2018.09.772. Epub 2018 Sep 22. PMID: 30253997.

Lukes A, Green MA. Three-Year Results of the SONATA Pivotal Trial of Transcervical Fibroid Ablation for Symptomatic Uterine Myomata. J Gynecol Surg. 2020 Oct 1;36(5):228-233. doi: 10.1089/gyn.2020.0021. Epub 2020 Oct 1. PMID: 33061253; PMCID: PMC7548023.

Marín Martínez ME, Cruz-Melguizo S, Vaquero Argüello G, Engels Calvo V, De la Cruz Conty ML, Pérez Medina T. Transvaginal radiofrequency ablation: a therapeutic option for managing symptomatic uterine fibroids in women with reproductive desires. F S Rep. 2024 Jul 15;5(3):320-327. doi: 10.1016/j.xfre.2024.07.001. PMID: 39381652; PMCID: PMC11456661.

Miller CE, Osman KM. Transcervical Radiofrequency Ablation of Symptomatic Uterine Fibroids: 2-Year Results of the SONATA Pivotal Trial. J Gynecol Surg. 2019 Dec 1;35(6):345-349. doi: 10.1089/gyn.2019.0012. Epub 2019 Dec 9. PMID: 32226268; PMCID: PMC7099422.

Nath I. D., Abdurazakova M. RADIOFREQUENCY ABLATION OF UTERINE FIBROIDS: ADVANCING MINIMALLY INVASIVE TREATMENT FOR WOMEN //Академические исследования в современной науке. – 2025. – Т. 4. – №. 13. – С. 17-21.

Piriyev E, Bends R, Schiermeier S, Romer T. Transcervical intrauterine radiofrequency ablation of fibroids in high-risk patients with bleeding disorder. Ginekol Pol. 2022;93(8):614-619. doi: 10.5603/GP.a2022.0042. Epub 2022 Jul 27. PMID: 35894488.

Pregnancy Outcomes After Laparoscopic Radiofrequency Ablation of Uterine Leiomyomas Compared With Myomectomy. Antoinette Allen 1, Michael Schembri, Ram Parvataneni, L Elaine Waetjen, Shira Varon, Naghmeh Salamat-Saberi, Shawn Tassone, Nicole Williams, Kimberly A Kho, Vanessa L Jacoby

Santalla-Hernández A, Naveiro-Fuentes M, Benito-Villena R, Villegas-Alcazar J, López-Criado MS, Lara-Serrano A, Parra JF, Alcázar JL, Pelayo-Delgado I. Complications of transvaginal radiofrequency ablation of fibroids: A 5-year experience. Eur J Obstet Gynecol Reprod Biol X. 2023 Oct 10;20:100244. doi: 10.1016/j.eurox.2023.100244. PMID: 37869066; PMCID: PMC10587728.

Shukurov F. I., Sattarova K. A., Razzakova N. S. INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE «ENDOSCOPIC SURGERY IN GYNECOLOGY AND REPRODUCTIVE MEDICINE»: International Experience and Development Perspectives //JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE. – 2024. – Т. 1. – №. 2. – С. 1-264.

Transcervical Fibroid Ablation (TFA): Update on Pregnancy Outcomes.Leslie Hansen-Lindner 1, Juliette Schmid-Lossberg 2, David Toub 3

Transcervical Radiofrequency Ablation of Symptomatic Uterine Fibroids: 2-Year Results of the SONATA Pivotal Trial Journal of Gynecologic Surgery, 2019.

Turtulici G, Orlandi D, Dedone G, Mauri G, Fasciani A, Sirito R, Silvestri E. Ultrasound-guided transvaginal radiofrequency ablation of uterine fibroids assisted by virtual needle tracking system: a preliminary study. Int J Hyperthermia. 2019 Jan 1;35(1):97-104. doi: 10.1080/02656736.2018.1479778. Epub 2018 Jul 17. PMID: 30012030.

Ultrasound Guided Percutaneous Radiofrequency Thermal Ablation of Symptomatic Uterine Fibroids — Results from a Single Center and 52 Weeks of Follow-Up Ginekologia Polska, August 2020.

Yüce G, Tayarer A, Keskin HL, Genc B, Canyigit M. Ultrasound guided percutaneous radiofrequency thermal ablation of symptomatic uterine fibroids - results from a single center and 52 weeks of follow up. Ginekol Pol. 2020;91(8):447-452. doi: 10.5603/GP.2020.0074. PMID: 32902841.

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Published

2025-04-22

How to Cite

NATH, I. D., & DILSHODOVNA, A. M. (2025). Radiofrequency Ablation of Uterine Fibroids: A Review of Techniques, Efficacy and Outcomes. International Journal of Integrative and Modern Medicine, 3(4), 125–133. Retrieved from https://medicaljournals.eu/index.php/IJIMM/article/view/1735