Drug Therapy in the Treatment of In flammatory Periodontal Diseases

Abstract

One of the most common inflammatory pathologies in adults is periodontal disease, which affects 70-90% of the world's population over the age of 40. To date, the multifactorial causes of pathology are clear, as well as the mechanisms of pathogenesis are almost revealed. Among them, the leading role is played by the microbial factor, a violation of microcirculatory mechanisms, as well as the severity of local immunity. Pathogenic microorganisms that cause periodontal diseases produce endotoxins that contribute to the progression of systemic diseases, including cardiovascular diseases, type 2 diabetes, respiratory tract infections, speech disorders, low self-esteem, and decreased quality of life. However, no highly effective therapy method has been proposed at the moment, and therefore the search for a combination of therapeutic factors contributing to the long-term remission of patients with inflammatory periodontal diseases continues. The current scientifically proven trend in the treatment of chronic inflammatory periodontal pathologies is to minimize surgical interventions, as well as to maximize the use of advanced conservative methods, which is achieved by using anti-inflammatory drugs and physical therapeutic effects. For local therapeutic effects on inflamed periodontal tissues , the drug celecoxib was chosen, which is a nonsteroidal anti-inflammatory drug by chemical nature that reduces swelling, redness of the mucous membrane, and reduces inflammatory phenomena. To prolong the effect of the drug, as well as as a detoxifying measure, polysorb was used together, which is proven capable of in vitro sorption of various drugs, their desorption in the inflammatory infiltrate, as well as persistent immobilization of microbes and their waste products. The aim of the study is to increase the effectiveness of drug and laser therapy in the treatment of inflammatory periodontal diseases. Gingivitis and periodontitis are inflammatory diseases caused by the penetration of infection into the soft tissues and bone structures supporting the teeth (into the periodontium). Genetic, environmental, and behavioral stereotypes, including bad habits and dietary patterns, are considered to be potentiating factors in the development of diseases. Periodontal diseases, especially mild and moderate-stage diseases, are widespread among the elderly worldwide, while the severe form is more common between the third and fourth decades of life, with a global prevalence of CVD of about 80-100%.