To Determine the Clinical Symptoms of the Systemic Inflammatory Response in Acute Severe Poisoning by Agents Affecting the Central Nervous System

The current stage of national healthcare is characterized by an increase in the number and severity of acute poisoning with drugs, which, according to the WHO International Classification of Diseases and Health-Related Problems of the 10th revision, are included in the T36-T50 group. According to the International Chemical Safety Program, accidental and intentional acute poisoning of medicinal origin accounts for up to 40-60% of all acute chemical pathology in the developed world. A similar pattern is observed in modern Russia, while 65-70% of acute drug poisoning is caused by drugs of psychopharmacological action (ICTC of the Ministry of Health of the Russian Federation, 2002). The most common psychotropic drugs that cause severe acute poisoning include the neuroleptic azaleptin (leponex) and the antidepressant amitriptyline, as well as combinations of psychotropic medications (Ostapenko Yu.N. et al., 2002). The severity of the condition of patients with acute poisoning is due, on the one hand, to the formation of exotoxic shock, on the other, to pronounced metabolic disorders with the development of endogenous intoxication syndrome (Kosonogoe L.F., 1995). As a result, multiple organ failure is formed, which is the direct cause of death (Luzhnikov E.A., Goldfabr Yu.S., 1995).