Tursunov Ravshan Sunnatilloyevich (1)
Atrial fibrillation (af) is the most common tachyarrhythmia, significantly impairing patients’ quality of life and work capacity. despite advancements in managing af, it remains a leading cause of stroke, heart failure, and sudden cardiac death worldwide. to meet the growing demand for effective treatment, new research is continually being conducted and published. in most cases, af is secondary, developing alongside other medical conditions. However, in at least one-third of patients, the cause of AF cannot be identified, leading to a diagnosis of idiopathic or primary AF. It is hypothesized that a significant proportion of idiopathic AF cases have a genetic basis. Even in secondary AF, a hereditary component may play a role, as not all patients with similar severity of an underlying condition develop AF. This opens possibilities for predicting, preventing, and treating this form of arrhythmia. This article reviews literature on the genetic mechanisms of atrial fibrillation, with findings that could significantly impact future treatment and prevention strategies.
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