Abstract:

Regarding the impact on male infertility, the study authors acknowledge that while a low sperm count is not a definitive indicator of infertility, it is closely linked to fertility where They explain that even when sperm concentration exceeds the threshold of 40-50 million/ml where The study aimed to conduct a systematic review of the study group that addressed the relationship between spermatogenesis and its relation to infertility in male patients while our Methodology Designed by This study systematically reviewed a collection of articles related to male infertility cases from 2017 to 2025 where A sophisticated scientific literature review was conducted to identify research findings as well as This study relied on articles indexed in the Google Scholar database as well as Based on the researched studies and the notes recorded in the results, which academically revealed the molecular mechanisms affecting sperm development, including H19 gene methylation patterns and genetic contributors to idiopathic sperm failure, the study also described the contributions and methodologies used in the research as well as Our findings summarize the comprehensive knowledge regarding the identification of molecular factors and their impact on male fertility, particularly the H19, MEST, and MTHFR imprinted genes, which are closely associated with infertility where found also is there relationship between Sperm metabolic characteristics, including amino acids such as arginine and lipids such as cholesterol and triglycerides.