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International Journal of Integrative and Modern Medicine

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Optimizing Modern Treatment of Knee Osteoarthritis in the Context of Type 2 Diabetes Mellitus

Vol. 3 No. 12 (2025): International Journal of Integrative and Modern Medicine:
Published : Dec 15, 2025

Akramov Vohidjon Rustamovich (1), Ziyadullaev Abdusalom Khabibullaevich (2), Abdulloev Mirshod Murodillo ogli (3)

(1) Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan
(2) Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan
(3) Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan
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Abstract:

Deforming osteoarthritis (OA) of the knee joint in the context of type 2 diabetes mellitus (T2DM) not only worsens the condition of patients but also requires improved treatment efficacy. This pathology affects a significant portion of the global population and is one of the leading causes of disability. In particular, OA in patients with diabetes tends to be clinically more severe, with pronounced morphological and immunological changes.


Within the study, a group of patients was examined using clinical, instrumental (X-ray and MRI), morphological, and immunohistochemical methods. They were divided into three groups:



  1. Control group – patients diagnosed with deforming osteoarthritis of the knee joint without diabetes, treated with conventional methods;

  2. Control group – patients diagnosed with knee DOA against the background of type 2 diabetes mellitus, treated with conventional methods;

  3. Experimental group – patients with knee DOA on the background of type 2 diabetes mellitus, who underwent the proposed minimally invasive surgical techniques (arthroscopy and neuroablation).


The results showed a high severity of diabetic DOA, with a significant decrease in CD3, CD20 lymphocytes, and the Ki-67 proliferation index. Minimally invasive surgical methods were more effective than conventional treatments in reducing pain syndrome, improving function, and decreasing the frequency of complications.


Conclusion: Modern minimally invasive technologies are an effective approach to optimizing the treatment of deforming osteoarthritis of the knee joint in patients with type 2 diabetes.

References

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2. Felson, D. T., & Zhang, Y. (1998). An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis & Rheumatism, 41(8), 1343–1355.

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5. Berenbaum, F. (2011). Diabetes-induced osteoarthritis: From a new paradigm to a new phenotype. Annals of the Rheumatic Diseases, 70(8), 1354–1356.