Ataullayeva Marjonabonu Sanjar qizi (1)
Chronic disease anemia (CHD) is the second most common form of anemia after iron deficiency anemia and is accompanied by a wide range of inflammatory, infectious, oncological, and autoimmune processes. The purpose of the study was to assess the prognostic significance of ferritin and the transferrin saturation coefficient (TSA) as key biomarkers that allow differentiating ASD, determining the depth of functional iron deficiency, and predicting the severity of the underlying disease. 120 patients with confirmed AH were examined, divided into three groups depending on the severity of the inflammatory process. It has been established that low CNT (<20%) and high ferritin (>200 ng/ml) significantly correlate with inflammation activity (CRP, ESR), organ damage severity, and disease duration. ROC analysis showed high diagnostic accuracy of the "ferritin + KNT" combination (AUC=0.87). The obtained data confirm that these indicators can be used as reliable prognostic markers in clinical and laboratory practice.
1. Marques, O. The role of iron in chronic inflammatory diseases. Blood Reviews, 2022.
2. Rohr, M. et al. How to diagnose iron deficiency in chronic disease: A review. European Journal of Medical Research, 2023.
3. Fertrin, K.Y. Diagnosis and management of iron deficiency in chronic disease. Hematology (American Society of Hematology Education Program), 2020. ASH Publications
4. Madu, A.J. et al. Anemia of chronic diseases: An in-depth review. Medical Principles and Practice, 2016.
5. de las Cuevas Allende, R. et al. Anemia of Chronic Disease: diagnosis and differentiation from iron deficiency. Journal of Clinical & Translational Pathology, 2021.
6. Badura, K., et al. Anemia of Chronic Kidney Disease - A Narrative Review of Its Mechanisms and Management. Journal of Clinical Medicine, 2024.
7. Peoc'h, K., et al. Iron deficiency in chronic inflammatory bowel diseases: the role of TSAT and ferritin. Journal of Laboratory and Precision Medicine, 2021.
8. Valitova A.D., Kadyrova Z.M., Oslopov V.N. et al. Chronic disease anemia: a verdict or a defensive reaction of the body? Kazan Medical Journal, 2023. Kazan Medical Journal