Mukhamadiyeva N. B. (1)
The study of pathogenetic predictors of the development of anxiety–depressive disorders in myocardial infarction (MI) will make it possible to develop approaches to their correction, thereby reducing the frequency of complications in the post-infarction period. To assess the mental status of the subjects, subjective methods were used, including the Hospital Anxiety and Depression Scale (HADS), designed for somatic hospital patients and recommended for use in individuals during the post-infarction period. Markers of endothelial dysfunction in blood plasma were determined by enzyme-linked immunosorbent assay using appropriate test systems. Since fibrinogen is one of the key factors in the blood coagulation process, disturbances of which—with a tendency toward thrombotic changes—represent a central link in the pathogenesis of MI, the level of oxidized fibrinogen was studied alongside indicators of the functional state of endothelial cells. The identified signs of thrombotic and hypercoagulable abnormalities in the hemostasis system in MI patients with depressive disorders possess high diagnostic value.
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