Agababyan Larisa Rubenovna (1), Usmankulova Xabiba Mizrobjonovna (2)
Polycystic ovary syndrome (PCOS) is a heterogeneous complex disorder characterized by oligo-anovulation, hyperandrogenism and/or hyperandrogenemia, and polycystic ovarian morphological changes. Interest in PCOS encompasses several specific aspects, including reproductive, cosmetic, and medical. Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder characterized by both metabolic and hormonal disorders and is a major cause of infertility in women. Much information has emerged in recent years to define the diagnostic criteria for this syndrome. In addition to hormonal aspects and metabolic abnormalities such as insulin resistance and obesity, susceptibility to developing earlier than expected glucose tolerance, the idea that these aspects should be included in the diagnostic criteria in order to develop potential therapeutic strategies is being considered. In addition, family history of SPCJ in families and in both female and male relatives may demonstrate stigmata of the syndrome, suggesting a genetic background.
1. Ali R. M. i dr. Geneticheskie assotsiatsi mejdu polimorfnimi lokusami genov fermentov antioksidantnoy zashiti GPX4 (rs713041), GSTP1 (rs1695) i PON1 (rs662) i sindromom polikistoznix yaichnikov u rossiyskix jenshin //Meditsinskaya genetika. – 2024. – T. 23. – №. 3. – S. 21-30.
2. Beglova A. Yu. i dr. Molekularno-geneticheskie osobennosti u jenshin s sindromom polikistoznix yaichnikov (SPKYa) //Mat i ditya v Kuzbasse. – 2019. – №. 3. – S. 48-53.;
3. Gasieva D. M. i dr. Sindrom polikistoznix yaichnikov: novie i perspektivnie varianti lecheniya //Problems of Endocrinology. – 2024. – T. 70. – №. 4. – S. 103.; Jurin N. V. i dr. KLINIKO-ANAMNESTICHESKIE FAKTORI RISKA BESPLODIYA PRI SPKYA I NARUJNOM GENITALNOM ENDOMETRIOZE //Mat i ditya v Kuzbasse. – 2024. – №. 2 (97). – S. 104-108.;
4. Yefimenko V. V. i dr. Novie aspekti v diagnostike i lecheni sindroma polikistoznix yaichnikov. Meditsinskiy Sovet. 2024;(6): 140–147 [Elektronniy resurs].;
5. Ibragimova, Nadiya Sabirovna, Baxodir Fikrievich Ibragimov, and Mashxura Akbar Kizi Mamadiyorova. "Sindrom polikistoznыx yaichnikov: osnovnыe momentы." Vestnik nauki i obrazovaniya 2-2 (105) (2021): 69-71;
6. Kashirina Ye. J., Maklakova T. P. OSOBENNOSTI PREGRAVIDARNOY PODGOTOVKI PRI ENDOKRINNIX ZABOLEVANIYAX. OBZOR LITERATURI //Meditsina v Kuzbasse. – 2024. – T. 23. – №. 2
7. Kudryavseva Ye. V. i dr. Seksualnaya funksiya u jenshin s besplodiem neyasnogo geneza: osobennosti i vliyanie na reproduktivnoe zdorove //Consilium Medicum. – 2024. – T. 26. – №. 7. – S. 415-419
8. Usmonkulova X. M. i dr. OSOBENNOSTI INDUKSII OVULYATSII JENSHIN S SINDROMOM POLIKISTOZNIX YaIChNIKOV //" ENGLAND" MODERN PSYCHOLOGY AND PEDAGOGY: PROBLEMS AND SOLUTION. – 2023. – T. 10. – №. 1.;
9. Bjekić-Macut J, Vukašin T, Velija-Ašimi Z, Bureković A, Zdravković M, Andrić Z, Branković M, Crevar-Marinović S, Madić T, Stanojlović O, Milutinović DV, Livadas S, Mastorakos G. Polycystic Ovary Syndrome: A Contemporary Clinical Approach. Curr Pharm Des. 2021;27(36):3812-3820. doi: 10.2174/1381612827666210119104721. PMID: 33463457
10. Chiaffarino F. et al. Prevalence of polycystic ovary syndrome in European countries and USA: A systematic review and meta-analysis //European Journal of Obstetrics & Gynecology and Reproductive Biology. – 2022. – Т. 279. – С. 159-170
11. Chiaffarino F. et al. Prevalence of polycystic ovary syndrome in European countries and USA: A systematic review and meta-analysis //European Journal of Obstetrics & Gynecology and Reproductive Biology. – 2022. – Т. 279. – С. 159-170
12. Cook H, Brennan K, Azziz R. Reanalyzing the modified Ferriman-Gallwey score: is there a simpler method for assessing the extent of hirsutism? Fertil Steril. 2011;96:1266–70.
13. Dunaif A, Fauser BC. Renaming PCOS-a two-state solution. J Clin Endocrinol Metab. 2013;98:4325–8.
14. Palomba S, Daolio J, La Sala GB. Oocyte quality and competence in women with polycystic ovary syndrome. Trend Endocrinol Metab. 2017;28:186–98
15. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41–7
16. Rusanova N. E. Infertility and fertility: demographic problems of assisted reproduction //Population and Economics. – 2024. – Т. 8. – №. 1. – С. 156-167.;
17. Stener-Victorin E, Teede H, Norman RJ, Legro R, Goodarzi MO, Dokras A, Laven J, Hoeger K, Piltonen TT. Polycystic ovary syndrome. Nat Rev Dis Primers. 2024 Apr 18;10(1):27. doi: 10.1038/s41572-024-00511-3. PMID: 38637590;
18. Zhu J. et al. Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome //The Journal of Clinical Endocrinology & Metabolism. – 2024. – Т. 109. – №. 2. – С. 380-388.
19. Wang Y. et al. Trends in the burden of female infertility among adults aged 20–49 years during 1990–2019: an analysis of data from the Global Burden of Disease Study 2019 //BMJ open. – 2024. – Т. 14. – №. 7. – С. e084755.