Molecular-Genetic Aspects of Arterial Hypertension Development in Obese Individuals
Keywords:
NOS3, C786T polymorphism, arterial hypertension, obesity, genetic predisposition, allele frequency, genotypesAbstract
The aim of the study was to evaluate the frequency of allelic and genotypic variants of the C786T polymorphism of the NOS3 gene in patients with arterial hypertension (AH) and obesity (O), as well as to study their possible role in the development of these pathologies. The study involved 382 people divided into a control group and groups with different combinations of AH and O. Analysis of allele and genotype frequencies showed a tendency to increase the frequency of the C allele in obese patients without AH compared to the control (p = 0.05), but no statistically significant differences were found between the other groups. The obtained data suggest a possible involvement of the C786T polymorphism of the NOS3 gene in the pathogenesis of obesity.
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