Khaydarova Barno Israiljanovna (1)
Acute ischemic stroke remains one of the leading causes of mortality and long-term disability worldwide, necessitating the development of effective neuroprotective strategies. Despite advances in reperfusion therapies such as thrombolysis and mechanical thrombectomy, neuronal injury caused by ischemia–reperfusion mechanisms continues to limit functional recovery. This article reviews innovative neuroprotective interventions aimed at reducing neuronal damage, modulating inflammatory responses, minimizing oxidative stress, and enhancing neuroplasticity. Emerging therapeutic approaches include targeted pharmacological agents, antioxidant and anti-inflammatory compounds, stem cell-based therapies, and combination treatment strategies integrated with reperfusion techniques. Additionally, the role of personalized medicine and biomarker-guided therapy is discussed as a promising direction in optimizing treatment outcomes. The integration of innovative neuroprotective interventions into standard stroke management protocols may significantly improve neurological recovery and reduce long-term disability.
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