Morphogenesis Of Adrenal Changes In Sudden Cardiac Death
Keywords:
sudden cardiac death, adrenal glands, morphogenesis, hypoxia, stress reaction, catecholamines, pathomorphology, hemodynamic disorders, degeneration, forensic medical diagnosticsAbstract
This study provides an in-depth analysis of the mechanisms of formation of morphological and pathomorphological changes in the adrenal glands in cases of sudden cardiac death. The study was conducted on the basis of 50 forensic medical examination materials, in which structural changes in the cortex and medulla of the adrenal glands were comprehensively studied. According to the results, disorders of the capillary system and stromal edema were identified as the most common changes in 84% of cases, which is associated with a sharp hemodynamic imbalance in the body. At the same time, granular degeneration at the cellular level was observed in 68% and cytoplasmic vacuolization in 58% of cases, which is explained by the excessive production of stress hormones. An increase in the activity of secretory cells in the medulla of the adrenal gland was noted in 76% of cases, which indicates a sharp increase in the secretion of catecholamines. In some cases (38%), microhemorrhages were detected, which were assessed as a result of circulatory disorders in the terminal stage. The obtained results show that morphological changes in the adrenal glands serve as an important diagnostic criterion in the pathogenesis of sudden cardiac death and can be used as additional evidence in forensic medical practice.
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