Association of Certain Gene Polymorphisms with the Risk of Atrial Fibrillation in Patients with Ischemic Heart Disease
Keywords:
atrial fibrillation, genetic study, renin-angiotensin system, human angiotensinogenAbstract
There is increasing evidence that gene-environment interactions play an important role in genetic studies of complex diseases. The renin-angiotensin system is a major regulator of blood pressure and cardiovascular homeostasis. AGT is an important component of the renin-angiotensin system. AGT is a precursor of angiotensin II, which causes acute vasoconstriction and stimulates proliferation of vascular muscle cells and cardiomyocytes. Many studies have evaluated the association of AGT T174M polymorphism with CHD risk, but the above observed associations consisted of a small number of samples, and the results may reflect chance observations rather than true associations.
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