Clinical and Genetic Features of Unstable Angina Pectoris Depending on Various Psychosocial Risk Factors

Unstable angina pectoris uric acid anxiety-depressive syndrome cytokine imbalance polymorphisms of IL-1β T/C 511 and IL-10 C/T 819 genes

Authors

  • Rizamat Ziyadullaevich Mirzaev Assistant of the Department of Internal Medicine and Cardiology Department №2, Samarkand State Medical University, Samarkand, Uzbekistan
  • Nasyrova Zarina Akbarovna DSc, Associate Professor of Internal Medicine and Cardiology Department №2 Samarkand State Medical University, Samarkand, Uzbekistan
  • Alam Mohd Shazeb Assistant of the Department of Internal Medicine and Cardiology Department №2, Samarkand State Medical University, Samarkand, Uzbekistan
April 5, 2024

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In our study we investigated the association of several biopsychosocial risk factors on the progression of unstable angina pectoris, in particular blood uric acid level, cytokine imbalance, anxiety-depressive syndrome, polymorphism of proinflammatory genes, and basic lipid spectrum parameters. We analyzed the correlation between the studied MC parameters, anxiety parameters, production of immunoregulatory cytokines, polymorphism of proinflammatory genes IL-1β T/C 511 (rs16944) and IL-10 T/C 819 (rs1800871), as well as cholesterol metabolism parameters.

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