Modern Perceptions on the Diagnosis and Treatment of Face Pain Syndromes
Downloads
Pain in the facial area (prosopalgia) is a complex, polyetiological, and clinically diverse group of pathological conditions, including nociceptive, neuropathic, and psychogenic forms. Among them, atypical facial pain occupies a special place, the pathogenesis of which is associated with the disruption of the central mechanisms of pain modulation and psycho-emotional disorders. The review presents modern data on the pathogenesis, classification, diagnosis, and treatment of various forms of facial pain, including odontogenic, myogenic, neuropathic, and psychogenic syndromes. Special attention was paid to the diagnostic difficulties in persistent idiopathic facial pain (PIFP) and the need for an interdisciplinary approach in therapy. Despite significant progress in the field of neurophysiology of pain, the pathogenetic mechanisms of this condition remain insufficiently studied, which necessitates further research aimed at identifying biomarker central sensitization and developing personalized treatment strategies.
1. Zakrzewska JM. Multi-dimensionality of chronic pain of the oral cavity and face. J Headache Pain. 2013;14:37.
2. Malacarne A, Ciarrocca M, Greco A, et al. Persistent dentoalveolar pain disorder: a comprehensive review. Oral Dis. 2018;24(8):1457–1464. (обзор PDAP/PIDAP).
3. Ziegeler C, Lueck J, et al. Idiopathic Facial Pain Syndromes: An Overview and Practical Diagnostic Approach. Schmerz. 2021;35(5):365–375. (обзор PIFP).
4. International Headache Society. The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1–211.
5. Gerwin RD. Chronic Facial Pain: A Narrative Review of Mechanisms and Treatment Strategies. Int J Environ Res Public Health. 2020;17(19):7012.
6. Gambeta E, Morton P, et al. Trigeminal neuralgia: from pathophysiology to treatment. Pain. 2020;161(5):1003–1019. (обзор патогенеза и лечения).
7. Rubis A, et al. The Use of Botulinum Toxin A in the Management of Orofacial Pain: A Systematic Review. J Pain Res. 2020;13:1867–1880. (систематический обзор)
8. Golanska P, et al. Temporomandibular Myofascial Pain Syndrome - Current Concepts and Therapeutic Approaches. J Clin Med. 2021;10(9):1887. (миофасциальная боль, обзор).
9. Kapos FP, et al. Temporomandibular disorders: a review of current concepts. J Am Acad Fam Physician. 2023; (rapid evidence review).
10. Азимова У.Э., Сергеев А.В., Табеева Г.Р. Персистирующая идиопатическая лицевая боль. Российский журнал боли / Pain Russia. (обзор на русском).
11. Erdogan O, et al. Outcomes of referrals from endodontic to orofacial pain specialists. J Orofac Pain. 2021; (исследование исходов при обращениях к специалистам по орофациальной боли).
12. Malacarne A. Review Article: Persistent Dentoalveolar Pain Disorder. J Endod. 2018; (обзор PDAP).
13. Tereshko Y. Botulinum Toxin Type A for Trigeminal Neuralgia - Review (2024). (современный обзор эффективности БТА при TN).
14. Kalladka M, et al. Myofascial pain in temporomandibular disorders: pathogenesis and management. Curr Opin Support Palliat Care. 2021.
15. Gambeta E, et al. Trigeminal neuralgia - clinical and pathophysiological aspects. Neuroscience & Biobehavioral Reviews. 2020.
16. RusMedReview / обзор PIFP (русск.). Персистирующая идиопатическая лицевая боль. (PDF обзор).
17. Research on referred odontogenic pain patterns (thesis / study). (исследование по отражённой боли зубного происхождения).
18. PainRussia - обзор и материалы по PIFP (русск.).
19. Cervantes-Chavarría AR, et al. Persistent Idiopathic Dentoalveolar Pain (PIDAP): literature review and case reports. J Orofac Pain. 2021.
20. ClinicalTrials.gov NCT06216886 / OnabotulinumtoxinA for Trigeminal Neuralgia (trial registration).
21. Frontiers in Neurology (2025) - исследования эффективности единичных vs множественных введений БТА при лицевой боли (новые данные).
22. Renton T. Dental (Odontogenic) Pain. Br Dent J. 2011; (обзор о боли зубного происхождения).
23. Coulter J. A review of persistent idiopathic dentoalveolar pain. Orofacial Pain Association resource (2020).
24. Rubis A. Botulinum Toxin in Orofacial Pain - hypothesis and trials. Toxins / J Pain Res. (см. обзоры 2020–2024).
25. ClinicalTrials.gov NCT02540863 - исследования миофасциальных вмешательств (реаб. методы).


