Study of the Effect of Darmonala Extract on Liver Functional State in Toxic Hepatitis

Toxic hepatitis Darmonala extract liver function

Authors

  • Karimova G.A Associate professor, Department of Pharmacology, normal and pathological physiology, Tashkent State Medical University
  • Kaldibayeva A.O Senior lecturer, Department of Pharmacology, normal and pathological physiology, Tashkent State Medical University
January 22, 2026

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In this study, the effect of Darmonala extract on liver function under conditions of toxic hepatitis was investigated. Based on my personal experience, the research materials included intact laboratory rats and rats with experimentally induced chronic toxic hepatitis, as well as their offspring. The results I obtained showed that liver pathologies in mother rats with toxic hepatitis caused significant changes in the postnatal ontogenesis of their offspring. In particular, in my opinion, dystrophic-destructive changes in hepatocytes, a decrease in glycogen content, vacuolization of hepatocytes, and cytoplasmic deformation were observed. From my observations, Darmonala extract may play a protective role in these processes, as its application helped maintain the stability of the liver’s morphometric and histological indicators.

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