Immunoinflammatory Aspects of Cytokine Imbalance in Juvenile Rheumatoid Arthritis in Children
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This research paper provides a detailed analysis of the immunological mechanisms underlying the pathogenesis of juvenile rheumatoid arthritis (JRA) and the role of key cytokines—IL-8, IL-17A, and IFN-γ—in shaping the inflammatory response and intercellular immune interactions. It has been established that cytokine imbalance initiates a cascade of immunological failures that contribute to the development of autoimmune reactions and chronic inflammation. The study included a comparative analysis of cytokine production in children with seronegative and seropositive JRA. The findings revealed a significant increase in IL-8 and IL-17A levels in the seropositive form of the disease, reflecting more pronounced inflammatory activity. Meanwhile, interferon-gamma (IFN-γ) levels were significantly reduced in both groups of patients. These results highlight the leading role of cytokine imbalance in the pathogenesis of JRA and the need for immunocorrective approaches in therapy.
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