Diagnosis of Dental Diseases in Children with Epilepsy
Keywords:
epilepsy, children, dental caries, gingival enlargement, antiepileptic drugs, oral hygiene, oral fluid, dental diagnosisAbstract
Background: Children with epilepsy are at increased risk of dental diseases because of the disease itself, the side effects of long-term antiepileptic therapy, comorbid neuropsychiatric disorders and difficulties in maintaining oral hygiene and cooperating during dental treatment. Aim: To summarise current evidence on the prevalence and structure of dental diseases in children with epilepsy and on the methods used for their diagnosis, and to propose a diagnostic algorithm for dental examination of this group. Methods: A narrative review of clinical, epidemiological and laboratory studies indexed in PubMed, Scopus, Google Scholar and eLIBRARY was carried out; quantitative results of comparative clinical studies were extracted and presented in tables and figures. Results: In a study of 100 children with epilepsy and 80 healthy controls, the mean dmf score was 4.1 versus 2.2 and the gingival index 1.16 versus 1.01. Among 107 children and adolescents aged 6–18 years, those taking antiepileptic drugs had higher DMFt (6.80 vs 4.65), CPITN (1.68 vs 0.96) and OHI-S (2.50 vs 1.53) scores. Drug-induced gingival enlargement, gingival bleeding in patients taking valproate, dental trauma during seizures and changes in the composition and antioxidant properties of oral fluid are additional diagnostic targets. Conclusion: Dental examination of children with epilepsy should include a structured medical history, index assessment of caries, hygiene and periodontal status, evaluation of drug-related oral effects and, where possible, analysis of oral fluid, and should be coordinated with the child’s neurologist.
References
[1] R. S. Fisher et al., “ILAE official report: A practical clinical definition of epilepsy,” Epilepsia, vol. 55, no. 4, pp. 475–482, 2014, doi: 10.1111/epi.12550.
[2] World Health Organization, “Epilepsy,” Fact sheet, 2024. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/epilepsy
[3] K. M. Fiest et al., “Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies,” Neurology, vol. 88, no. 3, pp. 296–303, 2017, doi: 10.1212/WNL.0000000000003509.
[4] W. Marcenes, N. J. Kassebaum, E. Bernabé, A. Flaxman, M. Naghavi, A. Lopez, and C. J. L. Murray, “Global burden of oral conditions in 1990–2010: A systematic analysis,” J. Dent. Res., vol. 92, no. 7, pp. 592–597, 2013, doi: 10.1177/0022034513490168.
[5] V. Baelum and R. López, “Periodontal disease epidemiology – learned and unlearned?” Periodontol. 2000, vol. 62, no. 1, pp. 37–58, 2013, doi: 10.1111/j.1600-0757.2012.00449.x.
[6] A. A. El Khatib, M. M. El Tekeya, M. A. El Tantawi, and T. Omar, “Oral health status and behaviours of children with autism spectrum disorder: A case–control study,” Int. J. Paediatr. Dent., vol. 24, no. 4, pp. 314–323, 2014, doi: 10.1111/ipd.12067.
[7] C. E. Aragon and J. G. Burneo, “Understanding the patient with epilepsy and seizures in the dental practice,” J. Can. Dent. Assoc., vol. 73, no. 1, pp. 71–76, 2007.
[8] World Health Organization, Oral Health Surveys: Basic Methods, 5th ed. Geneva, Switzerland: WHO, 2013.
[9] J. C. Greene and J. R. Vermillion, “The simplified oral hygiene index,” J. Am. Dent. Assoc., vol. 68, no. 1, pp. 7–13, 1964, doi: 10.14219/jada.archive.1964.0034.
[10] H. Löe and J. Silness, “Periodontal disease in pregnancy. I. Prevalence and severity,” Acta Odontol. Scand., vol. 21, no. 6, pp. 533–551, 1963, doi: 10.3109/00016356309011240.
[11] T. Gürbüz and H. Tan, “Oral health status in epileptic children,” Pediatr. Int., vol. 52, no. 2, pp. 279–283, 2010, doi: 10.1111/j.1442-200X.2009.02965.x.
[12] H. I. Morgan, R. K. Abou El Fadl, N. S. Kabil, and I. Elagouza, “Assessment of oral health status of children with epilepsy: A retrospective cohort study,” Int. J. Paediatr. Dent., vol. 29, no. 1, pp. 79–85, 2019, doi: 10.1111/ipd.12432.
[13] M. Mielnik-Błaszczak, A. Skawińska, A. Michałowski, J. Błaszczak, and K. Książek, “The impact of antiepileptic drugs on the condition of the oral cavity in children and youth affected with epilepsy,” Pol. J. Public Health, vol. 125, no. 2, pp. 110–112, 2015, doi: 10.1515/pjph-2015-0035.
[14] D. Tripodi, G. Cacciagrano, S. D’Ercole, A. Verrotti, and M. Tieri, “Effects of anti-epileptic drugs on the oral health of paediatric patients,” Eur. J. Paediatr. Dent., vol. 24, no. 1, pp. 45–48, 2023, doi: 10.23804/ejpd.2023.24.01.08.
[15] A. Dongari-Bagtzoglou, “Drug-associated gingival enlargement,” J. Periodontol., vol. 75, no. 10, pp. 1424–1431, 2004, doi: 10.1902/jop.2004.75.10.1424.
[16] R. A. Seymour, J. S. Ellis, and J. M. Thomason, “Risk factors for drug-induced gingival overgrowth,” J. Clin. Periodontol., vol. 27, no. 4, pp. 217–223, 2000, doi: 10.1034/j.1600-051x.2000.027004217.x.
[17] K. Károlyházy, E. Kovács, P. Kivovics, P. Fejérdy, and Z. Arányi, “Dental status and oral health of patients with epilepsy: An epidemiologic study,” Epilepsia, vol. 44, no. 8, pp. 1103–1108, 2003.
[18] F. E. Dewhirst, T. Chen, J. Izard, B. J. Paster, A. C. R. Tanner, W.-H. Yu, A. Lakshmanan, and W. G. Wade, “The human oral microbiome,” J. Bacteriol., vol. 192, no. 19, pp. 5002–5017, 2010, doi: 10.1128/JB.00542-10.
[19] V. Lazarevic et al., “Analysis of the salivary microbiome using culture-independent techniques,” J. Clin. Bioinform., vol. 2, Art. no. 4, 2012, doi: 10.1186/2043-9113-2-4.
[20] G. Dahlén, “Bacterial infections of the oral mucosa,” Periodontol. 2000, vol. 49, pp. 13–38, 2009, doi: 10.1111/j.1600-0757.2008.00295.x.
[21] J. M. Almerich-Silla, J. M. Montiel-Company, S. Pastor, F. Serrano, M. Puig-Silla, and F. Dasí, “Oxidative stress parameters in saliva and its association with periodontal disease and types of bacteria,” Dis. Markers, vol. 2015, Art. no. 653537, 2015, doi: 10.1155/2015/653537.
[22] O. Andrukhov, H. Haririan, K. Bertl, W. D. Rausch, H. P. Bantleon, A. Moritz, and X. Rausch-Fan, “Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: Possible gender aspect,” J. Clin. Periodontol., vol. 40, no. 10, pp. 916–923, 2013, doi: 10.1111/jcpe.12145.
[23] E. Pappa, E. Kousvelari, and H. Vastardis, “Saliva in the ‘Omics’ era: A promising tool in paediatrics,” Oral Dis., vol. 25, no. 1, pp. 16–25, 2019, doi: 10.1111/odi.12886.
[24] E. B. Parisotto et al., “Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome,” Res. Dev. Disabil., vol. 35, no. 6, pp. 1228–1236, 2014, doi: 10.1016/j.ridd.2014.03.013.
[25] S. Eckert et al., “Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries,” J. Hum. Genet., vol. 62, pp. 491–496, 2017.
[26] O. Norderyd et al., “Oral health of individuals aged 3–80 years in Jönköping, Sweden during 40 years (1973–2013). II. Review of clinical and radiographic findings,” Swed. Dent. J., vol. 39, no. 2, pp. 69–86, 2015.