Experimental Evaluation of the Anti-Adhesion Activity of Sodium Carboxymethylcellulose-Based Hydrogel

Purpose of the study. To evaluate the ant proliferative effect of a Na-CMC (carboxymethylcellullose) hydrogel in modulating the adhesion process in the abdominal cavity using experimental models with white rats.

Materials and methods. The experiment was conducted on 100 mature outbred female rats weighing 160-180 grams. The adhesion process in white rats was induced using a standard method: under general anesthesia, a midline laparotomy was performed, the cecum was brought out into the wound, and the adhesion process was modeled by deserosalizing the cecum with a gauze pad.

Results: The study demonstrated that the use of Na-CMC-based hydrogels significantly reduces the severity of the adhesion process in the abdominal cavity. The 3.5% hydrogel, in particular, was found to be especially effective, showing the least severity of adhesions on both the 7th and 10th days.

Conclusion: This study confirmed that Na-CMC-based hydrogels effectively reduce the severity of the adhesion process in the abdominal cavity.