Dynamics of Ferrokinetics Parameters in Patients With Rheumatoid Arthritis Associated With Helicobacter Pylori Infection on the Background of Complex Treatment Including Iron Preparations
Keywords:
rheumatoid arthritis, anemia, ferrokinetics, Helicobacter pylori, intestinal microbiota, iron preparationsAbstract
Despite certain advances in understanding the pathogenesis and developing new therapeutic approaches for rheumatoid arthritis (RA), achieving stabilization of its clinical course remains challenging. The presence of comorbid conditions such as anemia and gastroduodenal involvement poses a significant risk to patients' lives and entails substantial financial costs for the treatment and prevention of RA. Modern rheumatology pays special attention to the early detection of diseases. Currently, there is evidence that the preclinical period of systemic autoimmune reaction is associated with dysregulation of immune interactions with synanthropic microflora. This article discusses the disturbances in ferrokinetics in patients with rheumatoid arthritis associated with iron-deficiency anemia and H. pylori, as well as the results of correcting the anemic syndrome with iron preparations.
References
Khalaf, W. Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin / W. Khalaf, H. A. Al-Rubaie, S. Shihab // Hematol. Rep. - 2019. - Vol.11. - P. 7708.
Smolen, J.S. Rheumatoid arthritis / J.S. Smolen, D. Aletaha, I.B. McInnes // Lancet. - 2016. - Vol.388. - P. 2023-2038.
Hodkinson, B. Rheumatoid arthritis in the developing world: stepping up to the challenge / B. Hodkinson, M. Tikly, A. Adebajo // Clin. Rheumatol. - 2014. - Vol.33, No. 9. - P. 1195-1196.
Sparks, J. A. Rheumatoid arthritis and mortality among women during 36 years of prospective follow-up: results from the Nurses' Health Study / J.A. Sparks, S.C. Chang, K.P. Liao [et al.] // Arthritis Care Res. - 2016. - Vol. 68, No. 6. - P. 753-762.
Masson, C. Rheumatoid anemia / C. Masson // Joint Bone Spine. - 2011. - Vol. 78, No. 2. - P. 131-137.
Osman, K.S. Role of hepcidin in the pathogenesis of anemia not caused by iron deficiency / K.S. Osman, L.H. Aly, W. M. Abd El-Hamid [et al.] // J. Clin. Cell. Immunol. - 2014. - Vol.5, No. 1. - P. R193.
Kovalenko V.M. The likelihood of developing cytokine-mediated anemic syndrome in patients with rheumatoid arthritis / V.M. Kovalenko, G. P. Kuzmina, O. Ya. Markova // Ukrainian Rheumatological Journal. 2010. No. 2 (40). P. 33–38.
Agrawal S. Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients / S. Agrawal, R. Misra, A. Agrawal // Rheumatol Int. — 2006. — Vol. 26 (12). — P. 1091— 1095.
Tandra M. Iron deficiency in rheumatoid arthritic patients especially within the middle Age / M. Tandra, A. Srivastava // International Journal of Systems Biology. 2010. Vol. 2. P. 1–5.
Doyle M.K. Anemia in early rheumatoid arthritis is associated with interleukin 6-mediated bone marrow suppression, but has no effect on disease course or mortality / M.K. Doyle, M.U. Rahman, C. Han // J Rheumatol. 2008. Vol. 3. P. 380–386.
Galushko E.A. Anemia of chronic disease // Scientific and Practical Rheumatology. 2009. - No. 3. - P. 70-78
Suleimanova D.N., Saidov A.B., Narmetova M.U., Mamatkulova D.F., Davlatova G.N. Modern aspects of parenteral use of iron drugs in clinical practice. Methodological guide, 32 pages. Tashkent, 2018.
Grinshtein Y.I., Shabalin V.V., Kusaev V.V. Anemic syndrome in rheumatoid arthritis: approaches to diagnosis and therapy possibilities. Therapeutic Archive. - 2016. - 88(5). - P. 107-112
Zotagin V.V., et al. Analysis of anemic syndrome in patients with rheumatoid arthritis. - // Young Scientist. - 2019. - №23(261). - P. 164-166.
Dronov O.B., Kirilova V.A., Gilmudinova F.G.
The Role of Helicobacter pylori in the Development of Gastroesophageal Disease // Russian Journal of Gastroenterology, Hepatology, Coloproctology. Supplement №15.- 2001.-Vol. 11, №5. P.7.
Roviello F., Fotia G., Marrelli D., De Stefano A., Macchiarelli R., Pinto E. Iron deficiency anemia after subtotal gastrectomy for gastric cancer. Hepatogastroenterology. 2004; 51 (59): 1510-4.
Baysoy G., Ertem D., Ademoglu E., Kotiloglu E., Keskin S., Pehlivanoglu E. Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr. 2004; 38 (2):146-51.
Eshmurzaeva A.A., Sibirkina M.V. Ferrokinetics in Patients with Rheumatoid Arthritis. Eurasian Medical Research Periodical. 2023.Vol. 21. P. 20-27.
