Mohammed S. Altaee (1), Ansam Abdul Ghafoor Hasan (2)
This cross-sectional study examined the correlation between serum vitamin-D3 level and calcium, site specific BMD and BMC as obtained by DEXA in pre-and postmenopausal women from Pakistan. Serum concentrations of 25-hydroxyvitamin D3 (25(OH)D3) 1,25dihydroxyvitamin D3 [ ( OH 2 1,25(OH)2D3], calcium, and DEXA measurements of the femoral neck, lumbar spine (L2-L4), and other areas of the skeleton were measured in 100 adults (39 women, 61 men).
The relationships between serum 25(OH)D3 and BMD were in general inverse at the different sites, most pronounced in women, and the ratio 1,25(OH)2D3/25(OH)D3 correlated with makers of bone turnover. Women presented lower BMD and higher osteoporosis frequency at lumbar and femur sites. For men, however, the correlations were weaker and nonsignificant. The findings imply that sex-specific and site-specific aspects may need to be considered for the evaluation of bone health, and serum levels of vitamin D3 and calcium could be a practical serum marker for predicting the risk of osetoporosis in a clinical setting. Futher long-term longitudinal studies are required to elucidate causal relationships and inform patient-specific treatment strategies.
1. Fidel G. Siregar, M.; Jabbar, F.; H. Effendi, I.; Alhair, T. et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. (accessed 2024). ncbi.nlm.nih.gov
2. Murad, R.; Mahboob, T.; Rehman, R.; Baig, R. Comparison of serum levels of vitamin D and vitamin D-binding protein in normal, osteopenic and osteoporotic postmenopausal women. (accessed 2019). [PDF]
3. Fujita-Yamashita, M.; Yamamoto, K.; Honda, H.; Hanayama, Y. et al. Gender-Dependent Characteristics of Serum 1,25-Dihydroxyvitamin D/25-Hydroxyvitamin D Ratio for the Assessment of Bone Metabolism. (accessed 2021). ncbi.nlm.nih.gov
4. Khashayar, P.; Reza Aghaei Meybodi, H.; Rezai Hemami, M.; Keshtkar, A. et al. Vitamin D status and its relationship with bone mineral density in a healthy Iranian population. (accessed 2016). ncbi.nlm.nih.gov
5. M. Moran, J.; Gonzalez Lopez-Arza, L.; M. Lavado-Garcia, J.; Pedrera-Canal, M. et al. Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D. (accessed 2013). ncbi.nlm.nih.gov
6. Josiany Segheto, K.; Lopes Juvanhol, L.; Junqueira de Carvalho, C.; Cristina Guimarães da Silva, D. et al. Factors associated with bone mineral content in adults: a population-based study. (accessed 2019). ncbi.nlm.nih.gov
7. Mohammed, S. A., & Ibrahim, A. A. (2024). Dual Energy X-Ray Absorptiometry (Dexa) Changes And Body Mineral Density In Patient Had Skeletal Complication With Renal Function Impairment In Mosul.
8. Mohammed, S. A., (2025). Caffeine Consumption And Its Effects On Calcium And Vitamin D Levels In Patients With Osteomalacia.