Pathophysiology of TBI-Associated Hypopituitarism

Hypopituitarism associated with traumatic brain injury (TBI) has been considered a clinical condition for more than a century, since the first case was reported in 1918. Since 2000, several studies have convincingly proven that TBI-mediated pituitary hormone deficiency may be more common than previously thought. As a result of several studies, it has been seriously suggested that pituitary hormone deficiency mediated by TBI may be more common than previously thought. Gonadal hormone deficiency is the most common condition, followed by growth hormone deficiency, hypothyroidism, cortical hypofunction, and diabetes insipidus. Elucidating the pathophysiology of hypopituitarism, especially hypogonadism, is a real challenge for medicine.