Dynamics of Changes IN the Relationship of Hormones of the Reproductive System of Female Rats IN the Post-Intensive Care Period, After Modeling a 10-Minute Clinical Death
Keywords:
Clinical death, post-intensive care disease, autonomic nervous system, follicle stimulating hormone, luteinizing hormone, estradiol, progesteroneAbstract
Understanding the development of post-intensive care syndrome remains a pressing concern within the field of intensive care worldwide. The stress response triggered by extreme conditions is intricately linked to individual adaptation mechanisms within the autonomous nervous and neuroendocrine systems. Despite this interconnectedness, the impact of post-intensive care on the hormonal dynamics of the reproductive system remains relatively understudied in modern fundamental and clinical medicine. To address this gap, our study aimed to investigate the hormonal fluctuations in the reproductive system of female rats during the post-intensive care period. We conducted experiments on 80 sexually mature female rats, weighing between 160-180g and of mongrel, white descent, using a method pioneered by V.G. Korpachev in 1982 to induce clinical death and simulate post-resuscitation illness. We assessed both the reactivity of the autonomic nervous system and the hormone levels in the reproductive system of the female rats. During the early post-intensive care phase, characterized by a sympathetic nervous system dominance, a compensatory adaptive response was observed. This response facilitated the synthesis and secretion of follicle-stimulating hormone, luteinizing hormone, estradiol, and progesterone. However, in the long-term post-intensive care period, with a further increase in sympathetic nervous system activity, a decline in the levels of these hormones was noted. This downward trend indicated the onset of maladaptation, leading to a depletion of the reproductive system.
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