A Complication of During Pregnancy in Women With Polyembryo Seeding in Vitro Fertilisation

Assisted reproductive technologies (ART) account for approximately 1.9% and 4.5% of annual births in the United States and Europe, respectively. Delayed family planning has led to an increase in ART use. IVF poses a risk of multiple pregnancies; however, the increased use of single embryo transfer has reduced this risk.

Multiple embryo transfer is common in older women, leading to an increase in multiple pregnancies. Single blastocyst transfer also results in a higher incidence of twinning, presumably due to laboratory manipulation. The aim of this study was to evaluate pregnancy, labour and neonatal outcomes in IVF for multiple pregnancies compared with spontaneously conceived pregnancies based on a large US population-wide database. In this study, we found that IVF-assisted multiple pregnancies were more frequently complicated by pregnancy-induced hypertension, gestational hypertension, pre-eclampsia, gestational diabetes, and placenta previa.                     

This study showed that IVF multiple pregnancies have an increased risk of compared to spontaneous multiple pregnancies. This increased risk was previously shown to exist in single IVF pregnancies. Congenital anomalies were also more common and probably had the same pathophysiology as single pregnancy IVF. Based on the findings, assisted reproductive technology has both advantages and certain complications, which requires a rational approach to it.