Features of the Treatment of Sepsis in Complicated Diabetes Mellitus

Sepsis in patients with complicated diabetes mellitus presents a significant clinical challenge due to the interplay between the immune dysregulation caused by sepsis and the metabolic disturbances inherent in diabetes. This article explores the unique features of sepsis treatment in patients with diabetes, focusing on the pathophysiological mechanisms, diagnostic criteria, and therapeutic approaches. The dysregulated immune response in diabetes, which impairs both the recognition and clearance of pathogens, complicates the management of sepsis. Additionally, the metabolic imbalances such as hyperglycemia, insulin resistance, and diabetic ketoacidosis (DKA) exacerbate the septic state. This review evaluates current therapeutic strategies, including the use of broad-spectrum antibiotics, insulin therapy, fluid resuscitation, and adjunctive treatments such as corticosteroids and immunomodulatory agents. A particular emphasis is placed on the need for personalized treatment plans that take into account the severity of both diabetes and sepsis. Early identification, aggressive management, and continuous monitoring are critical for improving patient outcomes.