Expression of Circulating Microrna-199a and Microrna-155 in Chronic Viral Hepatitis B and Chronic Viral Hepatitis C
Keywords:
microRNA, gene expression, chronic viral hepatitis C, chronic viral hepatitis BAbstract
Viral hepatitis is one of the significant problems of hepatology in the world. Chronic viral hepatitis is known to have a high tendency to transform into liver cirrhosis and hepatocellular carcinoma. The high heterogeneity of the genomes of viral hepatitis and especially hepatitis C makes molecular characterization based not only on the determination of gene mutations and gene expression profiles, but also on new biological markers, fundamentally important. These new biomarkers are microRNAs (microRNA, miRNA, miR). Currently, a large amount of knowledge has been accumulated about changes in the expression of microRNAs in various pathologies, including chronic hepatitis, which makes it possible to create diagnostic and prognostic criteria based on microRNAs.
References
Akhmedova M.D., Tashpulatova S.A., Ikhtiyarova G.A., Karimova M.T. Chronic viral hepatitis B and D in pregnant women: course and outcomes (review). Journal Infectology. 2021;13(2):29-37. (In Russian)]. https://doi.org/10.22625/2072-6732-2021-13-2-29-37.
Гепатит B. Всемирная организация здравоохранения. Информационные бюллетени ВОЗ 2023 18.07. https://www.who.int/ru/news-room/fact-sheets/detail/hepatitis-b.
Новости ООН. Глобальный взгляд Человеческие судьбы. Борьбу с гепатитом нельзя откладывать: успешный опыт Узбекистана. https://news.un.org/ru/story/2021/07/1407172 [дата доступа: 18.07.2021].
Информационный бюллетень ВОЗ, июль 2019. Социальные аспекты здоровья населения. 2019;65(4).[WHO fact sheet, July 2019. Social aspects of population health. 2019;65(4). . (In Russian)] http://vestnik.mednet.ru/content/view 1093/30/lang,ru/ [дата доступа: 27.02.2023].
Kozlov D.S., Rodimova S.A., Kuznetsova D.S. The role of microRNAs in liver functioning: from biogenesis to therapeutic approaches (review). Sovremennye tehnologii v medicine 2023; 15(5): 54, https://doi.org/10.17691/stm2023.15.5.06
Ющук Н.Д., Малов С.И. и другие. Исследование сывороточной микроРНК-122 при гепатите С и ассоциированной с ним гепатоцеллюлярной карциноме//Вестник РАМН. — 2019. — Т.74. — №6. — С. 388–395
Юсупов Ш.Р., Аитов К.А., Савилов Е.Д., Абдуллаева Д.К., Умиров С.Э. Этиологическая характеристика хронических вирусных гепатитов в хорезмской области Узбекистана. Байкальский медицинский журнал. 2023;2(2):37-44. https://doi.org/10.57256/2949-0715-2023-2-37-44
Cabianca D.S., Casa V., Bodega B., et al. A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy. Cell. 2012; 149(4):819–831. [PubMed: 22541069].
Cermelli S. Circulating microRNAs in patients with chronic hepatitis C and non@alcoholic fatty liver disease / S. Cermelli, A. Ruggieri, J. A. Marrero // PLoS One 6. — 2011. — e23937.
Bader A.G. miR-34 – a microRNA replacement therapy is headed to the clinic.Front Genet. 2012; 3:120. [PubMed: 22783274].
Barry G., Briggs J.A., Vanichkina D.P., Poth E.M. The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Mol Psychiatry. 2014; 19(4):486– 94. [PubMed: 23628989].
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug@induced, and inflammatory liver dis@ eases / Bala S., Petrasek J., Mundkur S. [et al.] // Hepatology. — 2012. — Vol. 56. — P. 1946—1957
Ge J, Huang Z., Liu H, Chen J., Xie Z. et al. Lower Expression of MicroRNA-155 Contributes to Dysfunction of Natural Killer Cells in Patients with Chronic Hepatitis B //Front Immunol. 2017.- Sep;22;8:1173. doi:10.3389/fimmu. 2017.01173. eCollection 2017.
Kenneth J. Livak and Thomas D. Schmittgen. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2^-ΔΔCt Method //METHODS 25, 2001, 402-408 doi:10.1006/meth.2001.1262, available online at http://www.idealibrary. com.
Кучер А.Н., Бабушкина Н.П. Роль микро-РНК, генов их биогенеза и функционирования в развитии патологических состояний у человека / А.Н. Кучер, Н.П. Бабушкина // Медицинская генетика. – 2011. – № 1. – С. 3–13.
Gyongyi Szabo Shashi Bala. MicroRNAs in liver disease // Nat Rev Gastroenterol Hepatology. 2013.-September;10(9): 542-552. doi:10.1038/nrgastro.2013.87.
Chang C.C., Lin C.C., Hsieh W.L., Lai H.W., Tsai C.H., Cheng Y.W. MicroRNA expression profiling in PBMCs: a potential diagnostic biomarker of chronic hepatitis C //Dis Markers. 2014;2014:367157. doi: 10.1155/2014/367157. Epub 2014 Nov 18.
Jiao X., Fan Z., Chen H., He P., Li Y., Zhang Q., Ke C. Serum and exosomal miR-122 and miR-199a as a biomarker to predict therapeutic efficacy of hepatitis C patients //J Med Virol. 2017 Sep;89(9):1597-1605. doi: 10.1002/jmv.24829. Epub 2017 May 29.
Murakami Y., Aly H.H., Tajima A., Inoue I., Shimotohno K. Regulation of the hepatitis C virus genome replication by miR-199a //J Hepatol. 2009 Mar;50(3):453-60. doi:
1016/j.jhep.2008.06.010. Epub 2008 Jul 9.
Ge J, Huang Z., Liu H, Chen J., Xie Z. et al. Lower Expression of MicroRNA-155 Contributes to Dysfunction of Natural Killer Cells in Patients with Chronic Hepatitis B //Front Immunol. 2017.- Sep;22;8:1173. doi: 10.3389/fimmu.2017.01173. eCollection 2017.
Bala S., Tilahun Y., Taha O., Alao H., Kodys K., Catalano D., Szabo G. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection //J Transl Med. 2012. - Jul 30;10:151. doi: 10.1186/1479-5876-10-151.
Grek M., Piekarska A., Bartkowiak J., Fendler W. et al. Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells //Int J Mol Med. 2011. - Nov;28(5):875-80. doi: 10.3892/ijmm.2011.748. Epub 2011 Jul 12.
