Regulation of Somatotropic Hormone in Children, Dwarfism and Gigantism, Early Diagnosis and Treatment
Keywords:
Somatotropic hormone, pituitary gland, dwarfismAbstract
The somatotropic hormone (STH), also known as growth hormone (GH), is secreted by the anterior lobe of the pituitary gland and plays a crucial role in normal growth and development. This hormone regulates cell proliferation, protein synthesis, bone and muscle growth, as well as metabolic processes. In children, deficiency or excess secretion of GH leads to severe endocrine disorders — dwarfism and gigantism. Timely diagnosis and proper treatment are essential for ensuring a child’s healthy development and quality of life.
References
1. Melmed S., Polonsky K.S., Larsen P.R., Kronenberg H.M. Williams Textbook of Endocrinology. 14th ed. Philadelphia: Elsevier; 2020.
2. Jameson J.L., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J. Harrison’s Principles of Internal Medicine. 21st ed. New York: McGraw-Hill; 2022.
3. World Health Organization (WHO). Child growth standards and the identification of severe acute malnutrition in infants and children. Geneva: WHO; 2020.
4. Clayton P.E., Cianfarani S., Czernichow P., Johannsson G., Rapaport R., Rogol A. Management of the child born small for gestational age through to adulthood: A consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab. 2007;92(3):804–810.
5. Voutetakis A., Dracopoulou-Vabouli M., Livadas S. Disorders of growth hormone secretion and action in children. Ann Pediatr Endocrinol Metab. 2021;26(2):67–79.
6. Endokrinologiya ilmiy markazi, O‘zbekiston Respublikasi Sog‘liqni saqlash vazirligi. Bolalarda endokrin kasalliklar epidemiologiyasi bo‘yicha hisobot. Toshkent; 2023.
7. Ranke M.B., Wit J.M. Growth hormone — past, present and future. Nat Rev Endocrinol. 2018;14(5):285–300.
