Effectiveness of Target Therapy and its Complications in the Treatment of Polyangiitis Granulematosis

In the treatment of polyangiitis granulomatosis (PAG), the selective recommendation of gene-engineered biological drugs, the application of a combination of glucocorticoids and immunodepressants allow to increase the effectiveness of treatment and have a positive effect on the outcome of the disease. Early detection of PAG progression and complications, at the same time, assessment of important connections between clinical, biochemical and immunological manifestations of the disease, analysis of effective treatment methods and alternatives are of particular importance.

Despite many scientific researches conducted in different countries of the world, diagnosis and treatment of PAG, development of principles for predicting the complications and consequences of the disease, and identification of markers of negative consequences remain an urgent problem.