Significance of Presepsin in the Early Diagnosis of Sepsis in Children
Keywords:
pediatrics, pneumonia, sepsis, presepsinAbstract
Resume.
Infectious processes occurring in children of early age often have a non-specific clinical appearance. This, in turn, can lead to interpretation of symptoms and late diagnosis of the disease.
The purpose of the study is to determine the significance of the amount of presepsin in the blood plasma in the early diagnosis of sepsis in young children.
Materials and methods. 62 children with early age sepsis were included in the study. Among them, 27 patients made up the comparison group, i.e. children not complicated by sepsis, and 35 patients made up the main group - children with sepsis caused by pneumonia.
Result. When the level of presepsin was checked on the 1st-3rd days of hospitalization, it was found that the level of presepsin in the blood plasma of the patients of the main group was significantly higher than that of the patients of the control group. (358.9 [279.8 – 675.7] and 245.6 [125-353]). In addition, it was found that there is a correlation (r<0.05) between the duration of time the patients on the mechanical ventilator and the high level of presepsin in the blood (R=0.34; r=0.02).
Conclusion. Presepsin level in blood plasma exceeding 325 ng/l can serve as a diagnostic critery for the possibility of sepsis in the background of pneumonia.
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