Evaluating the Dose-Dependent Hepatotoxic Effects of Acetaminophen in Wistar Rats
Keywords:
Acetaminophen, Liver, RatsAbstract
Acetaminophen (APAP), a widely used analgesic and antipyretic, is known for its hepatotoxic potential when consumed in high doses. This study aims to evaluate the dose-dependent hepatotoxic effects of acetaminophen in Wistar rats by assessing changes in liver enzymes, histopathological findings, and biochemical markers of oxidative stress. Thirty adults male Wistar rats were divided into five groups (n=6): control, low-dose (500 mg/kg), medium-dose (1,000 mg/kg), high-dose (1,500 mg/kg), and toxic dose (2,000 mg/kg). The study demonstrated a significant increase in liver enzyme levels, oxidative stress markers, and histopathological damage at higher doses of APAP, indicating its dose-dependent hepatotoxicity.
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