Morphofunctional Foundations of the Development of Vascular Cognitive and Emotional Disorders
Keywords:
emotional disorders, cognitive disorders, arterial hypertension, cerebrovascular reactivityAbstract
Many studies have identified various risk factors and mechanisms that cause structural and functional changes in the brain in cerebral vascular disease (CVD). At the same time, the leading pathogenetic joint in the development of clinical signs of these syndromes remains ambiguous. Due to the frequent combination of dementia and depression in patients with cerebrovascular diseases, the term "2D syndrome" has been proposed to simplify their co-designation. It is known that the most common cause of dementia is Alzheimer's disease. "Pure" forms of Alzheimer's disease associated with increased genetically determined amyloid levels are rare, with most cases occurring sporadically, and are caused by typical changes in clearance mechanisms in the brain and amyloid beta accumulation.
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