The Relevance of Improving Measures for the Treatment of Tuberculosis of Peripheral Lymph Nodes

paradoxical responses pulmonary tuberculosis anti-tubercular medication

Authors

  • N. N. Parpieva Doctor of Medical Sciences, director of Ministry of Health of the Republic of Uzbekistan, Republican Specialized Scientific and Practical Medical Center of Phthisiology and Pulmonology named after Academician Sh. Alimov. Republic of Uzbekistan, Tashkent city
  • A. A. Adilkhodjaev Doctor of Medical Sciences, Scientific director of the Department of Extrapulmonary Organ Surgery of Ministry of Health of the Republic of Uzbekistan, Republican Specialized Scientific and Practical Medical Center of Phthisiology and Pulmonology named after Academician Sh. Alimov. Republic of Uzbekistan, Tashkent city
  • Z. A. Mo‘minova PhD of Ministry of Health of the Republic of Uzbekistan, Republican Specialized, Scientific and Practical Medical Center of Phthisiology and Pulmonology named after Academician Sh. Alimov. Republic of Uzbekistan, Tashkent city
October 8, 2025

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When it comes to treatment resistance, new infections, poor patient compliance, and adverse medication reactions, PR are more common in LNTB than in pulmonary tuberculosis. Despite the fact that the discovery of endosonography has greatly simplified the diagnosis of mediastinal LNTB, little is known about this condition. Investigating the clinical course of mediastinal LNTB and the risk variables linked to PR was the goal of this investigation. The mainstay of treatment for peripheral lymph node TB is a multi-drug anti-tuberculosis chemotherapy regimen, which typically lasts six months to a year and includes medications like rifampin and isoniazid. To lessen complications and enhance quality of life, surgery may also be considered for bigger nodes, abscesses, fistulas, or cases of treatment resistance and recurrence. To increase the body's resistance and stop recurrence, it's also critical to support general health through diet and exercise. Between 13.3% and 35.3% is the range of prevalences of PR linked to LNTB. PR can happen during antitubercular therapy or even after treatment is over; this is known as post-therapy PR. A PR onset might happen as soon as one month into treatment or as long as a year after starting an anti-tubercular medication. It is thought that a PR may result from a delayed hypersensitivity reaction and a decrease in immunological suppression. A nodal enlargement that already exists or the development of an abscess, sinus, or new nodal enlargement, or in rare cases, extra-nodal involvement, are the hallmarks of PR in LNTB. Granuloma, a positive acid-fast bacilli (AFB) smear, or a positive GeneXpert can all be signs of PR, an exclusionary diagnosis, but the AFB culture is usually negative.

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