SLEEP DISORDERS, METABOLIC SYNDROME, AND COGNITIVE ABILITIES IN ADOLESCENTS: CLINICAL AND PATHOPHYSIOLOGICAL RELATIONSHIPS
Keywords:
sleep disorders, metabolic syndrome, cognitive functions, adolescents, insomnia, insulin resistance, circadian rhythmsAbstract
The article presents a comprehensive analysis of the relationships between sleep disorders, metabolic syndrome, and cognitive functions in adolescents. Epidemiological data indicate a steady increase in the prevalence of both sleep disorders and metabolic syndrome in the pediatric population, which is accompanied by a significant decrease in cognitive abilities and academic performance. The pathophysiological mechanisms underlying these relationships are examined, including changes in neuroendocrine regulation, circadian rhythms, leptin and ghrelin levels, insulin resistance, oxidative stress, and neuroinflammation. It has been demonstrated that insufficient duration and quality of sleep contribute to the development of components of metabolic syndrome, while metabolic disorders, in turn, exacerbate sleep disorders and negatively affect cognitive functions. Special attention is paid to critical periods of neuroplasticity in adolescence and the impact of these disorders on the formation of neural networks responsible for executive functions, working memory, and attention. Modern diagnostic criteria and therapeutic strategies based on an interdisciplinary approach are presented, including lifestyle modification, sleep hygiene, dietary recommendations, and psychological support. The necessity of early diagnosis and timely correction of sleep disorders and metabolic disorders in adolescents is emphasized to prevent long-term negative consequences for cognitive functioning and psychosocial adaptation.
References
1. Nemkova S.A., Maslova O.I., Zavadenko N.N., Li T., Volodin N.N., Dorovskikh V.A., Karkashadze G.A., Mamedyarov A.M., Altunin V.V., Abashidze E.A., Kozhevnikova O.V., Nesterovsky Yu.E. Comprehensive diagnosis and correction of sleep disorders in children. Pediatric Pharmacology. 2015; 12 (2): 180–189. doi: 10.15690/pf.v12i2/1281)
2. Samuele Cortese, Anna Ivanenko, Ujjwal Ramtekkar, Marco Angriman SLEEP DISORDERS IN CHILDREN AND ADOLESCENTS // PRACTICAL GUIDE TO PSYCHIATRY AND PEDIATRICS, pp. 409-444
3. Otero Liliana, Figueredo María, Riveros Alain, Hidalgo Patricia. Cognitive Impairment and Obstructive Sleep Apnea. // 2019, 10.5772/intechopen.82756.
4. Yastrebova Anna Viktorovna Features of psychospeech development and sleep structure in preschool children with obstructive sleep apnea // abstract of dissertation for the degree of Candidate of Medical Sciences, Perm, 2018, 25 p.
5. Tadtaeva Z.G., Galustyan A.N., Rusanovsky V.V., Gromova O.A., Sardaryan I.S., Krivdina M.Yu., Kuritsyna N.A. Pharmacotherapy of insomnia in childhood. PHARMACOECONOMICS. Modern Pharmacoeconomics and Pharmacoepidemiology. 2022; № 15(2): pp. 284-293.
https://doi.org/10.17749/2070-4909/farmakoekonomika.2022.127
6. Kelmanson I.A. Sleep disorders and their relationship with emotional and behavioral disorders in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11):93-98.
7. Preobrazhenskaya I.S. Cognitive disorders and sleep disorders // "EFFECTIVE PHARMACOTHERAPY. Neurology 2015, №3 (23), pp. 20-28
8. Trosman, I., Trosman, S.J. Cognitive and Behavioral Consequences of Sleep Disordered Breathing in Children. Medical sciences (Basel, Switzerland), 2017. № 5(4),
