Kiyomov Ikhtiyor Ergashevich (1), Islamov Shavkat Erjigitovich (2)
The article presents morphological changes in the thymus of rats during chronic poisoning with the pesticide Ento Defol. At high doses of Ento Defol (1/20 LD50), reactive thickening of collagen fibers in interstitial barriers and perivascular zones was observed after 3–7 days. These changes were assessed as a compensatory response developing against a background of interstitial edema and microcirculatory disturbances. By days 14–30, high doses resulted in a significant increase in the relative area of collagen fibers, as well as an increased predominance of stromal elements against a background of disruption of the corticomedullary architecture. After 90 days, fibrotic processes stabilized, manifesting themselves in combination with an atrophic reduction in the lymphoid parenchyma. At this dose, the mast cell response was moderate: whereas activation was observed in the early periods, their numbers stabilized in later periods, and by day 90, a downward trend was observed.
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