Features of the Pharmacokinetics of Antipyrine in Patients with Uterine Myoma
Keywords:
myoma, pharmacokinetics, antipyrine, uterine fibroidAbstract
Uterine myoma is one of the most common malignant tumor diseases of female genital organs. The aim of this study was to investigate the pharmacokinetic parameters of antipyrine in patients with uterine myoma. The study included 33 patients aged between 37 and 57 years, with an average age of 43.8±0.6 years old. Among women of this group, 56.3% had gastrointestinal diseases and 69% had respiratory system diseases. We analyzed the most significant changes in antipyrine pharmacokinetics in the patients of the third group. Among them, the T1/2 and AUC indicators increased by 212.2% and 17%, respectively, while the MCR and Kel indicators decreased by 57.4% and 68.1%, respectively. According to the results of antipyrine test, the functional activity of MOS is clearly reduced in women with uterine fibroids. The decrease of the activity of MOS in patients with uterine fibroids also worsens in patients with hepato-biliary and respiratory system’s pathologies on the background of anemia.
References
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F. (2012) Screening for uterine tumours. Best Pract. Res. Clin Obstet.Gynaecol. 26:257–266.
Divakar H. (2008) Asymptomatic uterine fibroids. Best Pract. Res. Clin. Obstet. Gynaecol.22:643–654.
Sidorova I.S., Ryzhova O.V. (2002) The role of growth factors in the pathogenesis of uterine fibroids. Obstetrician and Gyn.12-13.
Wojtowicz K., Góra T., Guzik P., Harpula M., Chechliński P., Wolak E., Stryjkowska-Góra A. (2022) Uterine Myomas and Sarcomas - Clinical and Ultrasound Characteristics and Differential Diagnosis Using Pulsed and Color Doppler Techniques. J. Ultrason. 7;22(89):100-108. doi: 10.15557/JoU.2022.0017.
Bariani M.V., Rangaswamy R., Siblini H., Yang Q., Al-Hendy A., Zota A.R. (2020) The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis. CurrOpin Endocrinol Diabetes Obes. 27(6):380-387. doi: 10.1097/MED.0000000000000578.
Strizhova N.V., Sergeev P.V., Lisenko O.N. (1998) The role of sex hormones and their receptor apparatus in the choice of treatment methods in patients with endometrial hyperplastic processes in combination with uterine myoma. Obstetrician and Gyn.30-33.
Burra P., Masier A. (2004) Dynamic tests to study liver function//European Review for Medical and Pharmacological Sciences. 8:19-21.
Rakhmatov A.B. Khakimov Z.Z. Malishev L.S. (1999) Benzonal in treatment patients with psoriasi. News of dermatology and venerology. 3:48-51.
Nersesyan S.A., Araviyskiy R.A. , Grigoryan A.E. (2000) Antipyrine test as marker for evaluation disturbances antitoxic function of liver in treatment of dermatophytes with per os antimycotic drugs. News of dermatology and venerology. 6. 40-42
Ulrich M. Zanger, Schwab M. (2013) Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation// Pharmacology & Therapeutics. 138:1:103-141.
Tsuchiya Y., Nakajima M., Yokoi T. (2005) Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 28;227(2):115-124. doi: 10.1016/j.canlet.2004.10.007.
Raftogianis R., Creveling C., Weinshilboum R., Weisz J. (2000) Estrogen Metabolism by Conjugation, JNCI Monographs. 27: 113-124, https://doi.org/10.1093/oxfordjournals.jncimonographs.a024234.
Boichuk O.H., Agodi M.C. (2021) The Peculiarities of theData of Instrumental Examinations of Women Affected by Uterine Fibroids with Concomitant Hepatobiliary Diseases. World Science. 3:64:1-4. doi: 10.31435/rsglobal_ws/30032021/7508.
Salekh R.Kh., Peshev L.P., Siprov A.V.. (2010) Effect of progesterone and utrogestan on functional liver condition in patients with dysfunctional uterine bleed. Saratov Scientific Medical Journal. 6:3:549-552.
Khokhlova I.D., Kudrina E.A. (1996) Diagnosis and treatment of endometrial hyperplastic processes// Obstetrics and Gynecology. 4:50-52.
Tal R., Segars J.H. (2014) The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Hum Reprod Update. 20(2):194-216. doi: 10.1093/humupd/dmt042.
Husanghodjaeva M.T. (2018) Morphological, morphometric changes in momomatous nodes in women with uterine momory. European Science Review. 3/4: 211-214.
Kirschen, G. W., AlAshqar, A., Miyashita-Ishiwata, M., Reschke, L., El Sabeh, M., & Borahay, M. A. (2021). Vascular biology of uterine fibroids: connecting fibroids and vascular disorders. Reproduction. 162:2: 1-18. https://doi.org/10.1530/REP-21-0087/
Nazhmutdinov K.N. (1997) Monooxygenase system: state, problems and prospects of study. Medical journal of Uzbekistan. 11:12:10-12.
