Features of the Pharmacokinetics of Antipyrine in Patients with Uterine Myoma

Uterine myoma is one of the most common malignant tumor diseases of female genital organs. The aim of this study was to investigate the pharmacokinetic parameters of antipyrine in patients with uterine myoma. The study included 33 patients aged between 37 and 57 years, with an average age of 43.8±0.6 years old. Among women of this group, 56.3% had gastrointestinal diseases and 69% had respiratory system diseases. We analyzed the most significant changes in antipyrine pharmacokinetics in the patients of the third group. Among them, the T1/2 and AUC indicators increased by 212.2% and 17%, respectively, while the MCR and Kel indicators decreased by 57.4% and 68.1%, respectively. According to the results of antipyrine test, the functional activity of MOS is clearly reduced in women with uterine fibroids. The decrease of the activity of MOS in patients with uterine fibroids also worsens in patients with hepato-biliary and respiratory system’s pathologies on the background of anemia.