MOLECULAR ASPECTS OF ENDOMETRIAL HYPERPLASIA

Abstract

The frequency of occurrence of endometrial hyperplastic processes, the lack of effectiveness of therapy from hormonal therapy, as well as the likelihood of their malignancy puts endometrial hyperplastic processes among the most pressing problems of modern medicine. They are one of the very common causes of uterine bleeding and hospitalization of women in the hospital. A significant role in the formation of endometrial hyperplastic processes, along with hormonal disorders, is assigned to other activators of proliferative activity - growth factors, markers of proliferation and apoptosis, components of the extracellular matrix. Endometrial hyperplasia is a precancerous condition in which there is an uneven thickening of the uterine mucosa. This can cause unpleasant symptoms in women, including heavy menstruation, post menopausal bleeding, and anemia due to excess bleeding. Endometrial cancer is the most common gynecological malignancy in developed countries, and its incidence is increasing. Studying the molecular aspects of endometrial hyperplasia improves the results of treatment and prevention of carcinomas.