Morphological and Functional Changes of The Liver, Heart, And Kidneys in Obesity

Authors

  • Buriev Musurman Burievich European Multidisciplinary University (EMU University)
  • Xodjanov Surat Rakhmonberdievich Associate Professor, Department of Medical and Biological Sciences

DOI:

https://doi.org/10.31149/ijimm.v4i2.2678

Keywords:

Obesity, Hepatic Steatosis, Cardiac Remodeling, Renal Dysfunction, Organ Morphology, Metabolic Syndrome

Abstract

Obesity is a major global health challenge associated with structural and functional alterations in multiple organs, particularly the liver, heart, and kidneys. This study aimed to evaluate morphological and functional changes in these organs in patients with obesity and to determine their clinical significance. A total of 180 participants were included in the study, comprising 120 patients with obesity and 60 normal-weight controls. Clinical, biochemical, ultrasound, echocardiographic, and laboratory methods were applied. The findings demonstrated significant hepatic steatosis, left ventricular hypertrophy, and early nephropathy changes in obese individuals compared to controls. The results highlight the systemic impact of obesity and emphasize the importance of early diagnostic and preventive strategies.

References

World Health Organization. Obesity and overweight. Geneva: WHO; 2023.

Powell-Wiley T.M., Poirier P., Burke L.E., et al. Obesity and cardiovascular disease: A scientific statement from the American Heart Association. Circulation. 2021;143(21):e984–e1010. doi:10.1161/CIR.0000000000000973

Stefan N., Häring H.U., Cusi K. Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies. The Lancet Diabetes & Endocrinology. 2019;7(4):313–324. doi:10.1016/S2213-8587(18)30154-2

Byrne C.D., Targher G. NAFLD as a driver of chronic kidney disease. Journal of Hepatology. 2020;72(4):785–801. doi:10.1016/j.jhep.2019.09.013

Hall J.E., do Carmo J.M., da Silva A.A., Wang Z., Hall M.E. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circulation Research. 2019;124(4): 523–537. doi:10.1161/CIRCRESAHA.118.313897

Kovesdy C.P., Furth S.L., Zoccali C. Obesity and kidney disease: hidden consequences of the epidemic. American Journal of Nephrology. 2017;45(3):283–291. doi:10.1159/000456819

Packer M. Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium. JACC: Heart Failure. 2018;6(10):861–863. doi:10.1016/j.jchf.2018.06.005

Tilg H., Moschen A.R., Roden M. NAFLD and diabetes mellitus. Nature Reviews Gastroenterology & Hepatology. 2017;14(1):32–42. doi:10.1038/nrgastro.2016.147

Bluher M. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology. 2019;15(5):288–298. doi:10.1038/s41574-019-0176-8

Chagnac A., Weinstein T., Herman M., et al. The effects of weight loss on renal function in patients with severe obesity. Journal of the American Society of Nephrology. 2003;14(6):1480–1486.

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Published

2026-02-20

How to Cite

Burievich, B. M., & Rakhmonberdievich, X. S. (2026). Morphological and Functional Changes of The Liver, Heart, And Kidneys in Obesity. International Journal of Integrative and Modern Medicine, 4(2), 116–118. https://doi.org/10.31149/ijimm.v4i2.2678

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