Ultrasound Assessment of Thyroid Tissue Disorders in Women with Hypothyroidism Syndrome
DOI:
https://doi.org/10.31149/ijimm.v4i4.2874Keywords:
Thyroid Gland, Autoimmune Thyroiditis, Nodular Goiter, Hypothyroidism, Ultra-Sound Imaging, Thyroid Function, Reproductive Health, Iodine DeficiencyAbstract
Thyroid disorders are a significant public health concern, particularly in iodine-deficient regions where they have a particularly pronounced impact on women of reproductive age. This study aimed to evaluate the structural and functional alterations to the thyroid gland in women diagnosed with hypothyroidism syndrome, using ultrasound imaging and hormonal assessments. A comparative analysis was conducted between women with hypothyroidism and a euthyroid control group. The results showed a significantly higher prevalence of autoimmune thyroiditis in women with hypothyroidism, occurring around five times more frequently than in the control group. However, the incidence of nodular, mixed and multinodular goitre did not differ significantly between the groups, suggesting that these structural abnormalities may not be directly associated with hypothyroidism. Notably, thyroid hypoplasia was substantially more prevalent in patients with hypothyroidism, suggesting potential long-term endocrine and developmental implications. Conversely, thyroid enlargement was more prevalent in the control group, with grade I and grade II goitre detected in 44% and 66% of cases, respectively. These results could reflect compensatory mechanisms related to iodine deficiency rather than intrinsic thyroid dysfunction.Overall, the results emphasise the strong association between hypothyroidism and autoimmune processes affecting thyroid tissue, while also highlighting the complex interplay between environmental factors, such as iodine deficiency, and thyroid morphology. The study emphasises the importance of early diagnostic screening and targeted clinical management strategies to mitigate reproductive and metabolic complications in affected women.
References
[1] E. S. Shilova et al., “Diagnosis and treatment of subclinical hypothyroidism during pregnancy planning and pregnancy: A modern approach,” Problems of Endocrinology, vol. 66, no. 6, pp. 65–73, 2020.
[2] A. A. Eleukina, A. E. Nurmaganova, M. E. Korovina, and Z. B. Tauesheva, “Menstrual and reproductive function in thyroid pathology,” Scientific Discussion: Medicine Issues, no. 11(41), pp. 51–54, 2016.
[3] V. Kapustin et al., “Clinical aspects in obstetrics and women’s diseases,” Journal of Obstetrics and Women’s Diseases, vol. 70, no. 2, pp. 13–26, 2021.
[4] I. A. Mymrikova, T. V. Khripushina, and L. N. Sitnikova, “Influence of thyroid diseases on women’s reproductive health,” Youth Innovation Bulletin, vol. 1, no. 1, pp. 188–190, 2012.
[5] K. S. Bakhtina, V. A. Fedko, N. S. Bakhareva, and I. A. Chernyshev, “Menstrual cycle disorders in women of reproductive age with subclinical and overt hypothyroidism,” International Research Journal, no. 1(127), pp. 25–36, 2023.
[6] D. Yu. Beraya, “Restoration of reproductive function in women with autoimmune thyroid pathology,” Women’s Health, no. 8(84), p. 156, 2013.
[7] R. V. Kapustin et al., “Pregnancy and childbirth in a patient with long-term type 1 diabetes mellitus and antiphospholipid syndrome,” Journal of Obstetrics and Women’s Diseases, vol. 67, no. 6, pp. 93–99, 2018.
[8] T. M. Varlamova and M. Yu. Sokolova, “Women’s reproductive health and thyroid insufficiency,” Gynecology, vol. 6, no. 1, pp. 29–31, 2012.
[9] “The effect of thyroid hormones on the reproductive system,” in Proceedings of the 95th Scientific and Practical Conference of Students, Residents, Postgraduates, and Young Scientists, Perm State Medical University named after Academician E.A. Wagner, Perm, Russia, 2022, pp. 57–59.
[10] A. E. Gadzhizade, “Influence of thyroid diseases on female reproductive function,” Bulletin of Scientific Conferences, no. 2-1(66), pp. 27–28, 2021.
[11] N. V. Pasechko and S. V. Gnat, “Reproductive dysfunction in women with thyroid disorders (review),” International Journal of Endocrinology, no. 4(60), pp. 97–102, 2014.
[12] J. H. Lazarus, “Thyroid function in pregnancy,” British Medical Bulletin, vol. 97, no. 1, pp. 137–148, 2011.
[13] P. N. Taylor et al., “Guidelines for the management of thyroid disease in pregnancy,” Lancet Diabetes & Endocrinology, vol. 6, no. 7, pp. 575–586, 2018.
[14] American Thyroid Association, “Guidelines for diagnosis and management of thyroid disease,” Thyroid, vol. 27, no. 3, pp. 315–389, 2017.
[15] World Health Organization, “Assessment of iodine deficiency disorders and monitoring their elimination,” WHO Press, Geneva, 2007.