Diagnostic Value of Laboratory Analysis in Sialolithiasis: A Comprehensive Review
DOI:
https://doi.org/10.31149/ijimm.v4i6.2925Keywords:
Sialolithiasis, Laboratory Diagnostics, Saliva, Biomarkers, Calcium MetabolismAbstract
Sialolithiasis is one of the most common obstructive diseases of the salivary glands. Despite advances in imaging techniques, early diagnosis remains challenging. This study aims to evaluate the diagnostic significance of laboratory parameters in sialolithiasis based on a comprehensive literature review. Biochemical, immunological, and microbiological changes play a crucial role in the pathogenesis of salivary stone formation. Increased calcium concentration, altered salivary proteins, and inflammatory mediators contribute to stone development. The integration of laboratory diagnostics with clinical and imaging methods improves diagnostic accuracy and allows early detection of disease.
References
[1] J. Zenk and H. Iro, “Salivary gland diseases in daily practice,” Deutsches Ärzteblatt International, vol. 111, no. 51–52, pp. 866–873, 2014, doi:10.3238/arztebl.2014.0866.
[2] F. Marchal and P. Dulguerov, “Sialolithiasis management: the state of the art,” Archives of Otolaryngology–Head & Neck Surgery, vol. 129, no. 9, pp. 951–956, 2003, doi:10.1001/archotol.129.9.951.
[3] S. Kraaij, H. S. Brand, and I. van der Waal, “Salivary stone disease: symptoms, aetiology and treatment,” British Dental Journal, vol. 218, no. 9, p. E15, 2015, doi:10.1038/sj.bdj.2015.364.
[4] P. Capaccio, S. Torretta, and L. Pignataro, “The role of inflammation in salivary gland obstruction,” Acta Otorhinolaryngologica Italica, vol. 37, no. 3, pp. 176–182, 2017, doi:10.14639/0392-100X-1597.
[5] L. Mandel, “Calcium and salivary stone formation,” Journal of Oral and Maxillofacial Surgery, vol. 72, no. 9, pp. 1620–1624, 2014, doi:10.1016/j.joms.2014.04.028.
[6] L. R. Jumayev and S. J. Xamraev, “Evaluation of clinical and laboratory parameters in salivary gland diseases,” Journal of Medical Innovation, vol. 3, pp. 193–198, 2021.
[7] K. C. Huoh and D. W. Eisele, “Etiologic factors in sialolithiasis,” Otolaryngologic Clinics of North America, vol. 42, no. 6, pp. 927–947, 2009, doi:10.1016/j.otc.2009.08.003.
[8] L. R. Zhumayev, “Characteristics of immune system parameters in patients with sialosis,” Achievements of Science and Education, vol. 18, no. 40, pp. 82–84, 2018.
[9] L. R. Zhumayev and S. K. Pulatova, Indicators of Glycoproteins of Oral Fluid in Patients with Sialadenosis. Tashkent, Uzbekistan, 2020.
[10] L. R. Zhumayev, Analysis of Immune System Indicators in Patients with Sialosis. Bukhara, Uzbekistan, 2020.
[11] L. R. Zhumayev, Microbiological Picture of Salivary Gland Diseases. Bukhara, Uzbekistan, 2021.
[12] M. W. J. Dodds, D. A. Johnson, and C. K. Yeh, “Saliva and oral health,” Journal of Dentistry, vol. 43, no. 3, pp. 276–284, 2015, doi:10.1016/j.jdent.2014.10.009.
[13] M. Koch, J. Zenk, and H. Iro, “Epidemiology of salivary gland stones,” Otolaryngologic Clinics of North America, vol. 49, no. 2, pp. 327–338, 2016, doi:10.1016/j.otc.2015.10.005.
[14] M. B. Gillespie and B. P. O’Connell, “Prevention of recurrent sialolithiasis,” Laryngoscope, vol. 129, no. 2, pp. 369–374, 2019, doi:10.1002/lary.27355.
[15] H. S. Brand and E. C. I. Veerman, “Saliva: secretion and functions,” Monographs in Oral Science, vol. 24, pp. 1–7, 2014, doi:10.1159/000358783.
