Pathomorphological Features of The Ovaries in Infertile Women of Reproductive Age With Hypothyroidism

Abstract

The present study revealed that morphological alterations in the ovaries of women with hypothyroidism were characterized by developmental retardation of all morphofunctional components. Changes included an altered ratio between the cortical and medullary layers, as well as a hypercellular pattern within ovarian follicles. These findings predominantly reflected enhanced proliferation of mesenchymal cells, accompanied by a reduction in both the size and number of epithelial cells. In addition, ovarian blood vessels demonstrated increased volume and branching, while the medullary layer exhibited a marked expansion of mesenchymal tissue. Collectively, these observations indicate the predominance of metabolic disturbances within the ovaries under hypothyroid conditions.