Genetic Profile of Basal Cell Skin Cancer. Modern Concepts about Pathogenesis and Histopathology of the Disease

Abstract

Basal cell skin cancer (BCSC) has the highest prevalence in the group of non-melanoma skin tumors in the structure of cancer incidence. Histological subtypes of BCC have prognostically different dynamics of their morphology. The commonality of the tumor structure is that for each histological type, islands of tumor cells and the surrounding stroma are determined. Tumor cells resemble basal keratinocytes or hair follicle cells in appearance. The tumor is thought to originate from an undifferentiated pluripotent epithelial germ cell.