Morphometric Changes of the Spleen in Patients with Tumor Etiology

Abstract

This study describes the morphometry of spleen dimensions; compare the presence of a significant difference between sex and age. The study also assesses the determinant factors of spleen dimensions. In all, 86 spleen specimens were reviewed. The presence of each marrow-derived lineage, dysplasia . Neoplastic hematopoietic proliferations in chronic myeloproliferative disorders are characterized by trilineage hematopoiesis with significant dysplasia in all cell lineages. Acute myeloid leukemia showed an increase in immature forms, which were highlighted by immunohistochemistry. Reactive extramedullary hematopoiesis showed variability in histologic features. Post-bone marrow transplant and thrombotic thrombocytopenic purpura/hemolytic–uremic syndrome spleens showed extramedullary hematopoiesis with some morphologic features of immaturity, which could simulate chronic myeloproliferative disorder.