Morphofunctional Differentiations of the Spleen of White Rats in Normal and Abnormal Conditions
Keywords:
white rats, immune system, spleen, lymphatcytes, lymphoid follicles, chronic radiation sicknessAbstract
In an experimental study, morphofunctional features of the spleen of 3-month-old white rats in normal and chronic radiation sickness were studied. In the lymph nodes of the spleen of irradiated rats, the disappearance of germinative centers is observed. Irregular forms (32.4%) of LU are detected, which are not detected in the spleen of healthy rats. The width of the mantle, marginal, and periarterial zones decreases, as well as the total number of lymphocytes in the LU without a breeding center and PALM by 1.35 and 1.34 times, respectively. These data indicate that radioactive radiation has a negative effect on the lymphoid formations of the spleen, causing the development and formation of immunodeficiency.
References
Baimuradov R. R., Teshaev sh. Zh. Influence of different types of radiation on the male reproductive system // Problems of biology and medicine 2019, №4.2 2 (115). С. 208-210
Buklis Yu. V. Study of immune structures of the spleen in the conditions of chronic radiation exposure to the body / / Morphology.-2010. - Volume 137. - No. 4. - P. 42.
Kiryanov N. A. et al. Morphological characteristics of the immune and endocrine systems in endotoxicosis // Medical Bulletin of Bashkortostan. 2013. Vol. 8, No. 6. Pp. 156-158.
Teshaev sh. Zh., Baimuradov R. R. Morphological parameters of testes of 90-day-old rats in normal and under the influence of a biostimulator on the background of radiation exposure // Operative surgery and clinical anatomy 2020,4 (2), P.22-26.
Khasanova DA., Teshaev sh. Zh. Macroanatomy of lymphoid structures of the mesenteric part of the small intestine of rats in normal and on the background of chronic radiation sickness / / Morphology 2019, 156 (4), P. 51-55.
Chulkova S. V., Stilidi I. S., Glukhov E. V., Grevtsova L. Yu., Ned S. N., Tupitsyn N. N. the Spleen is a peripheral organ of the immune system. The influence of splenectomy on the immune status / / Bulletin of the N. N. Blokhin Russian Academy of medical Sciences, vol. 25, no. 1-2, 2014.
Karmaus W., Brooks K., Nebe T., Witten J., Obi-Osius N., Kruse H. Immune function biomarkers in children exposed to lead and organochlorine compounds: a cross-sectional study. // Environ. Healh. – 2005. – Vol.14. – №1. – P.5.
Kour K., Bani S. Augmentation of immune response by chicoric acid through the modulation of CD28|CNLA-4 and Th1 pathway in chronically stressed mice // Neuropharmacology. –2010.- V.60, №6. – P. 852-860.
Mebius R.E., Kraal G. Structure and function of the spleen // Nature Reviews Immunology. 2005. Vol. 5. P. 606–616
Turdiyev M. R., Teshayev Sh. J. Morphometric Assessment of Functional Immunomorphology of White Rat Spleen in the Age Aspect American Journal of Medicine and Medical Sciences 2019, 9(12): 523-526 DOI: 10.5923/j.ajmms.20190912.16.
Udoji F., Martin T., Etherton R., Whalen M.M. Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. // J. Immunotoxicol.–2010. – Vol.7. - №3. – Р.205-212
