Endogenous Intoxication and Microcirculation of Blood and Liver During Experimental Acute Intestinal Obstruction

Abstract

In the article, in order to determine the level of acute endogenous poisoning, the amount of medium molecular peptides OMP in the blood serum was determined. In acute experiential intestinal obstruction of obturation and strangulation (AIDQ), AIDQ is accompanied by strong endogenous intoxication in the body, this process depends on the form of the disease and its time. After the factor is restored, the amount of OMP decreases in the obturation form, and increases even more in the strangulation form.

Purpose: 54 male rats weighing 160-200 g were used in the experiments. In recent years, the role of medium molecular weight peptides in the implementation of structural and functional changes in cells and their importance in the development of endotoxemia has been determined. In order to determine the membrane toxic effect of endotoxins of medium molecular weight, we determined their content in the blood serum of experimental animals using Gabriel's method. Thus, the degree of endotoxemia and microcirculation disorders determines the severity of the imbalance in the LPO/AOD system. In the obstructive form, the elimination of obstruction reduces the indicators of endotoxemia and microcirculation, and in the form of strangulation, they increase.