Functional State of Local Immune Status in the Inflammatory Process in the Upper Respiratory Tract in Patients Infected with Covid-19

Abstract

In the period from 2020-2021, we examined COVID-19 infected 53 patients who applied to the infectious diseases department of the Bukhara Regional Infectious Diseases Medical Center. Of these, 32 people suffered from acute rhinosinusitis and 21 people-acute purulent tonsillitis. All patients underwent a standard examination: clarification of complaints and anamnestic data. Examination of the upper respiratory tract organs was carried out according to the generally accepted scheme.

We also studied the indicators of local immunity of the mucous membranes of the upper respiratory tract using immunohistochemical studies with antibodies to T-helper lymphocytes (CD4 +), suppressor T-lymphocytes (CD8 +) and B-lymphocytes (CD20) in patients of different groups.

Indicators of local immunity of the mucous membrane of the nasal cavity and pharynx in the first two weeks of the acute process correspond to an adequate response of local immunity to an infectious agent; the third week is characterized by an imbalance of local immune protection, which indicates a high activity of the inflammatory process, which is a milestone in the course of the disease.