Morphofunctional Differentiations of the Spleen of White Rats in Normal and Abnormal Conditions

white rats immune system spleen lymphatcytes lymphoid follicles chronic radiation sickness

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July 16, 2024

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In an experimental study, morphofunctional features of the spleen of 3-month-old white rats in normal and chronic radiation sickness were studied. In the lymph nodes of the spleen of irradiated rats, the disappearance of germinative centers is observed. Irregular forms (32.4%) of LU are detected, which are not detected in the spleen of healthy rats. The width of the mantle, marginal, and periarterial zones decreases, as well as the total number of lymphocytes in the LU without a breeding center and PALM by 1.35 and 1.34 times, respectively. These data indicate that radioactive radiation has a negative effect on the lymphoid formations of the spleen, causing the development and formation of immunodeficiency.

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