Prevalence of H. Pylori Infection in Pediatrics. Cross-Sectional Study (200 Cases)

Authors

  • Dr. Naseer Salih Fadhil M.B.Ch.B., F.I.B.M.S. \ (Pediatric), Iraqi Ministry of Health, Basrah Health Directorate, Basrah Maternity and Pediatric Hospital, Basrah, Iraq
  • Dr. Hamsa Shakir Abdulnabi M.B.Ch.B., F.I.C.M.S., C.A.B.P. \ (Pediatric), Specialist Paediatrician, Iraqi Ministry of Health, Basrah Health Directorate, Department of Paediatrics Basra Teaching Hospital, Basrah, Iraq
  • Dr. Shaimma Jassim Marheg M.B.Ch.B., C.A.B.P., F.I.C.M.P. \ (Pediatric), Iraqi Ministry of Health, Diayla Health Directorate, Alkhalis General Hospital, Diayla, Iraq
  • Abbas AbdulWahhab Jumaah Al-Salihi M.Sc. \ (Sciences in Genetic Engineering and Biotechnology \ Molecular Biology), Department of Applied Embryology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Nahrain University, Kadhimiya, Baghdad, Iraq
  • Dr. Ali Qais Abdulkafi M.B.Ch.B., D.C.H. \ (Pediatrics), Iraqi Ministry of Health, Kirkuk Health Directorate, Kirkuk Teaching Hospital, Kirkuk, Iraq

Keywords:

H. pylori infection, Children, Complications, Quality Life Questionnaire

Abstract

Helicobacter pylori infection is highly prevalent in more than 60% of the world's population and causes serious clinical complications that negatively affect children's quality of life over the long term. This study aims to evaluate and analyze the clinical outcomes that describe the extent of the prevalence of H. pylori infection in children. Between February 2023 and August 2024, 200 children with H. pylori infection between 4 and 15 years old who were diagnosed clinically in different hospitals in Iraq were recruited. These findings found that children with ages 13 – 15 years were the most class which has h. Pylori Infection which include 80 cases, where males had 90 cases and females had 110 cases; the most symptom prevalence in children was abdominal pain with 84 cases, and drinking contaminated water was the h. Pylori Infection sources, which are prevalent in children with 50% of total patients, peptic ulcers and inflammation of the stomach lining were the items as adverse outcomes as resulted in children with 100 cases and 40 cases. In general, children are considered the most affected age group by the spread of H. pylori, which weakens the histological features of the gastric mucosa in children, causing severe complications that negatively affect their daily lives.

References

Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014;19 Suppl 1:1–5.

Zabala Torrres B, Lucero Y, Lagomarcino AJ, Orellana-Manzano A, George S, Torres JP, et al. Review: prevalence and dynamics of Helicobacter pylori infection during childhood. Helicobacter. 2017;22

Lim SH, Kwon JW, Kim N, Kim GH, Kang JM, Park MJ, et al. Prevalence and risk factors of Helicobacter pylori infection in Korea: a nationwide multicenter study over 13 years. BMC Gastroenterol. 2013; 13:104.

Rhee KH, Youn HS, Baik SC, Lee WK, Cho MJ, Choi HJ, et al. Prevalence of Helicobacter pylori infection in Korea. J Korean Soc Microbiol. 1990; 25:475–90.

O'Ryan ML, Rabello M, Cortés H, Lucero Y, Peña A, Torres JP. Dynamics of Helicobacter pylori detection in stools during the first five years of life in Chile, a rapidly developing country. Pediatr Infect Dis J. 2013; 32:99–103.

Seo JH, Youn JH, Kim EA, Jun JS, Park JS, Yeom JS, et al. Helicobacter pylori antigens are inducing an early immune response in infants. J Korean Med Sci. 2017; 32:1139–46.

Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Dig Liver Dis. 2008; 40:490–6.

Seo JH, Park JS, Rhee KH, Youn HS. Diagnosis of Helicobacter pylori infection in children and adolescents in Korea. Pediatr Gastroenterol Hepatol Nutr. 2018; 21:219–33.

Lee SY, Ko JS, Seo JK. Changes in the prevalence of biopsy-proven Helicobacter pylori infection in Korean children with functional recurrent abdominal pain over the last 18 years. Korean J Pediatr Gastroenterol Nutr. 2009; 12:150–5.

Malaty HM, Kim JG, Kim SD, Graham DY. Prevalence of Helicobacter pylori infection in Korean children: inverse relation to socioeconomic status despite a uniformly high prevalence in adults. Am J Epidemiol. 1996;143:257–62.

Jang KM, Choe BH, Choe JY, Hong SJ, Park HJ, Chu MA, et al. Changing prevalence of helicobacter pylori infections in Korean children with recurrent abdominal pain. Pediatr Gastroenterol Hepatol Nutr. 2015; 18:10–6.

Yang HR. Updates on the diagnosis of Helicobacter pylori infection in children: what are the differences between adults and children? Pediatr Gastroenterol Hepatol Nutr. 2016; 19:96–103.

Seo JH, Park JS, Yeom JS, Lim JY, Park CH, Woo HO, et al. Correlation between positive rate and number of biopsy samples on urease test in childhood Helicobacter pylori infection. J Korean Med Sci. 2014;29:106–9.

Lim SH, Kim N, Kwon JW, Kim SE, Baik GH, Lee JY, et al. Trends in the seroprevalence of Helicobacter pylori infection and its putative eradication rate over 18 years in Korea: a cross-sectional nationwide multicenter study. PLoS One. 2018;13: e0204762.

Urita Y, Watanabe T, Kawagoe N, Takemoto I, Tanaka H, Kijima S, et al. Role of infected grandmothers in transmission of Helicobacter pylori to children in a Japanese rural town. J Paediatr Child Health. 2013; 49:394–8.

Michel A, Pawlita M, Boeing H, Gissmann L, Waterboer T. Helicobacter pylori antibody patterns in Germany: a cross-sectional population study. Gut Pathog. 2014;6:10.

den Hollander WJ, Holster IL, van Gilst B, van Vuuren AJ, Jaddoe VW, Hofman A, et al. Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city. Gut. 2015; 64:1200–8.

Patterson T, Straten E, Jimenez S. The prevalence of Helicobacter pylori antibody in different age groups in Central Texas. Clin Lab Sci. 2012; 25:102–6.

Muhsen K, Lagos R, Reymann MK, Graham DY, Pasetti MF, Levine MM. Age-dependent association among Helicobacter pylori infection, serum pepsinogen levels, and immune response of children to live oral cholera vaccine CVD 103-HgR. PLoS One. 2014;9: e83999.

Fuenmayor-Boscán AD, Hernández IM, Valero KJ, Paz AM, Sandrea LB, Rivero Z. Association between Helicobacter pylori and intestinal parasites in an Añu indigenous community of Venezuela. Indian J Gastroenterol. 2016; 35:106–12.

Ghasemi-Kebria F, Ghaemi E, Azadfar S, Roshandel G. Epidemiology of Helicobacter pylori infection among Iranian children. Arab J Gastroenterol. 2013; 14:169–72.

Senbanjo IO, Oshikoya KA, Njokanma OF. Helicobacter pylori-associated with breastfeeding, nutritional status, and recurrent abdominal pain in healthy Nigerian children. J Infect Dev Ctries. 2014; 8:448–53.

Oleastro M, Pelerito A, Nogueira P, Benoliel J, Santos A, Cabral J, et al. Prevalence and incidence of Helicobacter pylori Infection in a healthy pediatric population in the Lisbon area. Helicobacter. 2011; 16:363–72.

Serrano CA, Talesnik E, Peña A, Rollán A, Duarte I, Torres J, et al. Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-β Eur J Gastroenterol Hepatol. 2011; 23:656–63.

Parzecka M, Szaflarska-Popławska A, Gasiorowska J, Gorzkiewicz M, Grzybowski T. The prevalence of dupA (duodenal ulcer-promoting gene) of Helicobacter pylori in children and adolescents: own observation. Pol Merkur Lekarski. 2013; 34:277–80.

Gijsbers CF, Benninga M, Büller H. Clinical and laboratory findings in 220 children with recurrent abdominal pain. Acta Paediatr. 2011; 100:1028–32.

Elitsur Y, Alrazzak BA, Preston D, Demetieva Y. Does Helicobacter pylori protect against eosinophilic esophagitis in children? Helicobacter. 2014; 19:367–71.

Youn HS, Baik SC, Cho YK, Woo HO, Ahn YO, Kim K, et al. Comparison of Helicobacter pylori infection between Fukuoka, Japan and Chinju, Korea. Helicobacter. 1998; 3:9–14.

Okuda M, Osaki T, Lin Y, Yonezawa H, Maekawa K, Kamiya S, et al. Low prevalence and incidence of Helicobacter pylori infection in children: a population-based study in Japan. Helicobacter. 2015;20:133–8.

Den Hollander WJ, Holster IL, den Hoed CM, van Deurzen F, van Vuuren AJ, Jaddoe VW, et al. Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi-ethnic European city. J Gastroenterol Hepatol. 2013; 28:1705–11.

Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the ¹³C-Urea breath test. BMC Public Health. 2013; 13:1215.

Kivi M, Tindberg Y, Sörberg M, Casswall TH, Befrits R, Hellström PM, et al. Concordance of Helicobacter pylori strains within families. J Clin Microbiol. 2003; 41:5604–8.

Cho MJ, Lee WK, Jeon YS, Kim KH, Kim SH, Baik SC, et al. Intrafamilial transmission of Helicobacter pylori detected by random amplified polymorphic DNA fingerprinting. Mol Cells. 1995; 5:508–13.

Benajah DA, Lahbabi M, Alaoui S, El Rhazi K, El Abkari M, Nejjari C, et al. Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco) Clin Res Hepatol Gastroenterol. 2013; 37:519–26.

Mathewos B, Moges B, Dagnew M. Seroprevalence and trend of Helicobacter pylori infection in Gondar University Hospital among dyspeptic patients, Gondar, North West Ethiopia. BMC Res Notes. 2013; 6:346.

Kim MS, Kim N, Kim SE, Jo HJ, Shin CM, Lee SH, et al. Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. Helicobacter. 2013; 18:135–42.

Yan TL, Hu QD, Zhang Q, Li YM, Liang TB. National rates of Helicobacter pylori recurrence are significantly and inversely correlated with the human development index. Aliment Pharmacol Ther. 2013; 37:963–8.

Jun JS, Seo JH, Park JS, Rhee KH, Youn HS. Changes in the treatment strategies for Helicobacter pylori infection in children and adolescents in Korea. Pediatr Gastroenterol Hepatol Nutr. 2019; 22:417–30.

Downloads

Published

2024-10-16

How to Cite

Fadhil, D. N. S., Abdulnabi, D. H. S., Marheg, D. S. J., Al-Salihi, A. A. J., & Abdulkafi, D. A. Q. (2024). Prevalence of H. Pylori Infection in Pediatrics. Cross-Sectional Study (200 Cases). International Journal of Pediatrics and Genetics, 2(10), 20–26. Retrieved from https://medicaljournals.eu/index.php/IJPG/article/view/1041